Inhalation challenges with occupational agents: Threshold duration of exposure
| Autor: | Olivier Vandenplas, Vinciane D'Alpaos, Geneviève Evrard, Jacques Jamart |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine medicine.medical_specialty Air Pollutants Occupational Bronchial Provocation Tests Drug Administration Schedule Specific inhalation challenge stomatognathic system Forced Expiratory Volume Occupational Exposure Administration Inhalation medicine Humans Asthma Occupational Duration (project management) Retrospective Studies Inhalation Exposure Inhalation business.industry Middle Aged medicine.disease Asthma Bronchoprovocation tests Molecular Weight Anesthesia Emergency medicine Occupational diseases Female business Occupational asthma |
| Zdroj: | Respiratory Medicine. 107(5):739-744 |
| ISSN: | 0954-6111 |
| DOI: | 10.1016/j.rmed.2013.01.008 |
| Popis: | SummaryObjectivesThe aim of this study was to characterize the threshold duration of exposure needed to elicit an asthmatic reaction during specific inhalation challenges (SIC) with various occupational agents and to determine the duration of exposure that should be completed before the test can be considered negative.MethodsThis retrospective study analysed the cumulative duration of challenge exposure that was required to elicit a ≥20% fall in forced expiratory volume in one second in 335 consecutive subjects with a positive SIC.ResultsThe threshold duration of challenge exposure required to induce an asthmatic reaction was ≤60 min in 179 (53%) subjects, between 61 and 120 min in 74 (22%) subjects, and longer than 120 min in 82 (25%) subjects. The multivariate linear regression analysis showed that a longer duration of exposure was associated with exposure to low-molecular-weight agents (p |
| Databáze: | OpenAIRE |
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