High expression of adenylate cyclase-associated protein 1 accelerates the proliferation, migration and invasion of neural glioma cells
| Autor: | Yunfeng Wang, Wenjuan Chen, Donglin Wang, Na Ban, Jie Sun, Xiaojun Qiu, Weikang Xing, Shaochen Fan, Zhen Bao, Gang Cui |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male 0301 basic medicine Pathology medicine.medical_specialty Cell Cycle Proteins Kaplan-Meier Estimate Biology Pathology and Forensic Medicine Flow cytometry 03 medical and health sciences 0302 clinical medicine Downregulation and upregulation Cell Movement Cell Line Tumor Glioma medicine Humans Gene silencing Neoplasm Invasiveness Cell Proliferation medicine.diagnostic_test Brain Neoplasms Cell growth Cell Biology Middle Aged Flow Cytometry Prognosis medicine.disease Immunohistochemistry Up-Regulation Cytoskeletal Proteins 030104 developmental biology medicine.anatomical_structure Cell culture Gene Knockdown Techniques 030220 oncology & carcinogenesis Cancer research Female Astrocyte |
| Zdroj: | Pathology - Research and Practice. 212:264-273 |
| ISSN: | 0344-0338 |
| Popis: | Adenylate cyclase-associated protein 1 (CAP1), a conserved member of cyclase-associated proteins was reported to be associated with the proliferation, migration or invasion of the tumors of pancreas, breast and liver, and was involved in astrocyte proliferation after acute Traumatic Brain Injury (TBI). In this study, we sought to investigate the character of CAP1 in the pathological process of human glioma by detecting human glioma specimens and cell lines. 43 of 100 specimens showed high expression of CAP1 via immunohistochemistry. With statistics analysis, we found out the expression level of CAP1 was correlated with the WHO grades of human glioma and was great positively related to Ki-67 (p |
| Databáze: | OpenAIRE |
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