The effect of Madopar on the pharmacokinetics of ropinirole in healthy Chinese volunteers
| Autor: | Xiao-Xing Luo, Lin-Lin Bi, Dafang Zhong, Xiaoyan Chen, Yanyan Jia, Aidong Wen |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Levodopa Indoles Clinical Biochemistry Pharmaceutical Science Pharmacology Placebo Sensitivity and Specificity Dopamine agonist Analytical Chemistry Antiparkinson Agents Benserazide Asian People Pharmacokinetics Reference Values Tandem Mass Spectrometry Drug Discovery medicine Aromatic Amino Acid Decarboxylase Inhibitors Humans Drug Interactions Enzyme Inhibitors Chromatography High Pressure Liquid Spectroscopy Volume of distribution Cross-Over Studies Chemistry Reproducibility of Results Crossover study Drug Combinations Ropinirole Linear Models Female medicine.drug |
| Zdroj: | Journal of Pharmaceutical and Biomedical Analysis. 43:774-778 |
| ISSN: | 0731-7085 |
| Popis: | Ropinirole is a nonergoline dopamine D(2)-receptor agonist and has been proven to be effective in both monotherapy and combination therapy for idiopathic Parkinson's disease. The purpose of the present study was to examine the effect of Madopar on the pharmacokinetics of ropinirole in healthy Chinese volunteers by using liquid chromatography tandem mass spectrometry (HPLC/MS/MS). A single dose of 1mg ropinirole was given orally after administration of the placebo or Madopar (containing 200 mg levodopa and 50 mg benserazide) to six healthy males and six healthy females in a cross-over randomized study with a minimum washout period of 8 days. Pharmacokinetic parameters were calculated for both treatments. Coadministration of ropinirole and Madopar did not result in a notable change in rate or extent of availability of ropinirole, as shown by the ratios (90% confidence intervals) of 1.045 (0.900, 1.222) for C(max) (maximum plasma concentration) and 1.167 (1.086, 1.262) for AUC(0-inf) (the area under the concentration-time curve). Likewise, no significant difference in any of the other pharmacokinetic parameters [T(max) (the time needed to reach the C(max)), MRT (mean residence time), volume of distribution (V/F), and clearance (CL/F)] was observed between the treatment groups. No clinically relevant adverse effects were detected under either conditions and there are no pharmacokinetic grounds for adjusting the dose of ropinirole when given in combination with Madopar in Chinese patients. |
| Databáze: | OpenAIRE |
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