New Concepts in the Radiological Assessment of COPD
| Autor: | Robert M. Rogers, Harvey O. Coxson |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine Pathology medicine.medical_specialty Disease Critical Care and Intensive Care Medicine Sensitivity and Specificity Severity of Illness Index Pathogenesis Pulmonary Disease Chronic Obstructive Airway resistance Parenchyma medicine Genetic predisposition Humans COPD business.industry Genetic disorder respiratory system Airway obstruction medicine.disease respiratory tract diseases Radiographic Image Enhancement Pulmonary Emphysema Female Tomography X-Ray Computed business |
| Zdroj: | Seminars in Respiratory and Critical Care Medicine. 26:211-220 |
| ISSN: | 1098-9048 1069-3424 |
| Popis: | Chronic obstructive pulmonary disease (COPD) is a complex genetic disorder in which environmental factors, such as tobacco smoke, interact with genetic susceptibility to cause disease. Airway obstruction in COPD is due to an exaggerated inflammatory response that ultimately destroys the lung parenchyma (emphysema) and increases airway resistance by remodeling the airway wall. Until recently, assessment of these disease processes required the examination of resected tissue. However, computed tomography (CT) now allows researchers to measure the structure of the lung parenchyma and airway wall without having to remove the tissue. This review describes some of the new CT techniques for quantitative assessment of lung structure. These techniques are extremely important to study the pathogenesis of COPD as well as differentiate patients with predominantly emphysema disease from those with airway wall remodeling, and to assess the effects of therapeutic interventions. |
| Databáze: | OpenAIRE |
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