Long-term progression-free survival after early autologous transplantation for mantle-cell lymphoma
| Autor: | Jonathan L. Kaufman, H.J. Khoury, Martha Arellano, Leonard T. Heffner, Edmund K. Waller, M.J. Lechowicz, Sujatha Murali, Amelia Langston, Sagar Lonial, Karen P. Mann, Elliot F. Winton, Chris I. Flowers |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Salvage therapy Hematopoietic stem cell transplantation Lymphoma Mantle-Cell Transplantation Autologous Dexamethasone Disease-Free Survival Recurrence hemic and lymphatic diseases Antineoplastic Combined Chemotherapy Protocols medicine Autologous transplantation Humans Progression-free survival Survival rate Cyclophosphamide Aged Salvage Therapy Transplantation business.industry Hematopoietic Stem Cell Transplantation Induction chemotherapy Hematology Middle Aged medicine.disease Surgery Survival Rate Doxorubicin Vincristine Mantle cell lymphoma Female business Follow-Up Studies |
| Zdroj: | Bone marrow transplantation. 42(8) |
| ISSN: | 1476-5365 |
| Popis: | Autologous hematopoietic progenitor SCT (HPCT) has been studied both as a consolidative and salvage maneuver in mantle-cell lymphoma (MCL), and may improve failure-free survival rates as well as overall survival. We describe 21 patients with MCL who received autologous HPCT at Emory University Hospital as part of the primary treatment strategy. Sixteen patients were in CR1 and five in PR1 at the time of HPCT. The most commonly used induction chemotherapy was the hyper-CVAD (cyclophosphamide, vincristine, doxorubicin and dexamethasone) regimen with or without rituximab. At the last follow-up, 17 patients were in continuous CR, and there were four relapses. There were no transplant-related deaths. With a median follow-up of 54 months from HPCT, 5-year progression-free survival and overall survival are 73% and 76%, respectively. Our retrospective analysis provides the longest follow-up to date for patients with MCL who received an autologous HPCT as part of primary treatment. This lengthy follow-up helps define the natural course of MCL after autologous transplantation. |
| Databáze: | OpenAIRE |
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