The effect of varying doses of d-amphetamine on activity levels of prepubertal mice
| Autor: | Albert S. Cytryn |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Activity level
Male medicine.medical_specialty Dextroamphetamine Dose medicine.medical_treatment Mice Inbred Strains Motor Activity Toxicology Mice Inbred strain Species Specificity Baseline activity Internal medicine medicine High activity Animals Sexual Maturation Amphetamine Saline Biological Psychiatry Dose-Response Relationship Drug Chemistry Psychiatry and Mental health Endocrinology medicine.drug |
| Zdroj: | Psychiatry research. 3(1) |
| ISSN: | 0165-1781 |
| Popis: | The effect of varying doses of d -amphetamine on the activity level of C57BL/6J mice (known for their high activity level), DBA/1J, C3H/HeJ, and C 3 D 2 F 1 mice was investigated (all mice were 25 to 30 days old). Activity was measured by the use of an activity cage with a revolving drum. After determination of baseline activity level, the animals were assigned to the following set of i.p. injections: (1) normal saline, (2) d -amphetamine 0.2mg/kg, (3) d -amphetamine 0.5 mg/kg, (4) d -amphetamine 5mg/kg. The mean activity level of the C57BL/6J mice was significantly higher than that of the other strains. The mean activity level after 5 mg/kg was significantly lower than after other dosages in all strains. All strains responded similarly to d -amphetamine as is apparent from the parallel profiles for the dose-response curves. The response of the developing mice to d -amphetamine is at variance with the known response of mature mice. |
| Databáze: | OpenAIRE |
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