Hearing Outcomes of Treatment for Acute Noise-induced Hearing Loss: A Systematic Review and Meta-analysis
| Autor: | Sina Koochakzadeh, Shaun A. Nguyen, Paul R. Lambert, Prashant N. Bhenswala, Theodore R. McRackan, Jonathan Kil, Avigeet Gupta |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Hearing loss 03 medical and health sciences 0302 clinical medicine Hearing Internal medicine otorhinolaryngologic diseases medicine Humans Prospective Studies 030223 otorhinolaryngology Hyperbaric Oxygenation Absolute threshold of hearing business.industry Data synthesis Evidence-based medicine medicine.disease Sensory Systems Clinical trial Treatment Outcome Hearing Loss Noise-Induced Otorhinolaryngology Data extraction Meta-analysis Neurology (clinical) medicine.symptom business 030217 neurology & neurosurgery Noise-induced hearing loss |
| Zdroj: | Otology & Neurotology. 41:e971-e981 |
| ISSN: | 1537-4505 1531-7129 |
| Popis: | OBJECTIVE To determine the efficacy of various treatment modalities used for acute noise-induced hearing loss (aNIHL) from acute acoustic trauma (AAT) via a systematic review and meta-analysis. DATA SOURCES PubMed, Cochrane, and Scopus databases. STUDY SELECTION The scientific literature was searched up to October 2018 for articles evaluating hearing outcomes after treatment of aNIHL. DATA EXTRACTION The following were extracted: Oxford level of evidence, number of patients, mean age, time to presentation, source of noise exposure, method of treatment/intervention, baseline hearing threshold, posttreatment hearing threshold, hearing gain, proportion of patients with no recovery, partial recovery, or complete recovery, and treatment complications. DATA SYNTHESIS Sixteen studies with 932 patients met inclusion criteria for systematic review and four studies with 187 patients were included in the meta-analysis. CONCLUSIONS Treatment modalities identified were steroids, vascular agents, nootropics, antioxidants, vitamins, cell apoptosis inhibitors, and hyperbaric oxygen therapy. Meta-analysis demonstrated significant improvement in mean hearing threshold for patients with high-frequency hearing loss, those treated within 48 hours, and those receiving treatment with a nootropic agent. Significant heterogeneity was present in experimental design among included studies and many were of lower levels of evidence. More prospective, large scale, randomized, double-blinded, placebo-controlled clinical trials are required to determine optimal treatment regimens for patients suffering from aNIHL caused by AAT. |
| Databáze: | OpenAIRE |
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