Oxidative Stress of Carbon Nanotubes on Proteins Is Mediated by Metals Originating from the Catalyst Remains
| Autor: | Atsushi Hirano, Momoyo Wada, Hiromichi Kataura, Takeshi Tanaka |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
General Physics and Astronomy
02 engineering and technology Carbon nanotube 010402 general chemistry Protein oxidation 01 natural sciences Redox Catalysis law.invention Nanomaterials Reaction rate Electron transfer Protein structure law Transition Elements General Materials Science Chemistry Nanotubes Carbon General Engineering Proteins 021001 nanoscience & nanotechnology 0104 chemical sciences Oxidative Stress Chemical engineering 0210 nano-technology |
| Zdroj: | ACS nano. 13(2) |
| ISSN: | 1936-086X |
| Popis: | Nanomaterials introduced into biological systems are immediately coated by proteins in vivo. They induce oxidative stress on adsorbed proteins and hence alter the protein structures, which determines the fate pathways and biological impacts of nanomaterials. Carbon nanotubes (CNTs) have been suggested to cause protein oxidation. In this work, we discovered that CNTs induce oxidative stress on proteins in cooperation with coexisting metals originating from catalyst remains. Protein sulfhydryl groups were readily oxidized by the coexistence of CNTs and metals. Numerical simulations of the reaction demonstrated that the metals effectively mediate electron transfer between the CNTs and protein sulfhydryl groups. Thus, the coexistence of CNTs and metals, even in low concentrations, generates oxidative stress on proteins with high reaction rates. Metal catalysts used for CNT growth, in turn, catalyze the oxidation reaction of proteins. The proposed protein oxidation mechanism will advance the fundamental understanding of the biological safety and toxicity of nanomaterials synthesized using metal catalysts. |
| Databáze: | OpenAIRE |
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