Insights into Thymus Development and Viral Thymic Infections

Autor: Giuseppe Fiume, Francesco Albano, Ileana Quinto, Camillo Palmieri, Eleonora Vecchio, Carmen Caiazza, Valentina Pagliara, Angelica Avagliano, Alessandro Arcucci, Giuseppe Donato, Massimo Mallardo, Maurizio Renna, Enrico Iaccino, Selena Mimmi
Přispěvatelé: Albano, F., Vecchio, E., Renna, M., Iaccino, E., Mimmi, S., Caiazza, C., Arcucci, A., Avagliano, A., Pagliara, V., Donato, G., Palmieri, C., Mallardo, M., Quinto, I., Fiume, G.
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Viruses, Vol 11, Iss 9, p 836 (2019)
Viruses
ISSN: 1999-4915
Popis: T-cell development in the thymus is a complex and highly regulated process, involving a wide variety of cells and molecules which orchestrate thymocyte maturation into either CD4+ or CD8+ single-positive (SP) T cells. Here, we briefly review the process regulating T-cell differentiation, which includes the latest advances in this field. In particular, we highlight how, starting from a pool of hematopoietic stem cells in the bone marrow, the sequential action of transcriptional factors and cytokines dictates the proliferation, restriction of lineage potential, T-cell antigen receptors (TCR) gene rearrangements, and selection events on the T-cell progenitors, ultimately leading to the generation of mature T cells. Moreover, this review discusses paradigmatic examples of viral infections affecting the thymus that, by inducing functional changes within this lymphoid gland, consequently influence the behavior of peripheral mature T-lymphocytes.
Databáze: OpenAIRE
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