Maternal hemoglobin and hematocrit levels during pregnancy and childhood lung function and asthma. The Generation R Study
| Autor: | Herman T. den Dekker, Sabrina M. C. B. Pereira de Jesus, Johan C. de Jongste, Eric A.P. Steegers, Liesbeth Duijts, Irwin K.M. Reiss, Vincent W. V. Jaddoe |
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| Přispěvatelé: | Epidemiology, Erasmus MC other, Pediatrics, Obstetrics & Gynecology |
| Rok vydání: | 2018 |
| Předmět: |
Pulmonary and Respiratory Medicine
Spirometry Adult Hypersensitivity Immediate Vital capacity medicine.medical_specialty Population Vital Capacity Hematocrit 03 medical and health sciences Hemoglobins 0302 clinical medicine Pregnancy Risk Factors Surveys and Questionnaires medicine Humans 030212 general & internal medicine Longitudinal Studies Prospective Studies education Prospective cohort study Child Life Style Lung Asthma education.field_of_study medicine.diagnostic_test Obstetrics business.industry Pregnancy Complications Hematologic Pregnancy Outcome Anemia medicine.disease 3. Good health 030228 respiratory system Socioeconomic Factors Prenatal Exposure Delayed Effects Pediatrics Perinatology and Child Health Generation R Female business |
| Zdroj: | Pediatric Pulmonology Pediatric Pulmonology, 53(2), 130-137. Wiley-Liss Inc. |
| ISSN: | 8755-6863 |
| DOI: | 10.1002/ppul.23733 |
| Popis: | textabstractObjective: To examine the associations of maternal hemoglobin and hematocrit levels during pregnancy with childhood lung function and asthma, and whether adverse pregnancy outcomes and atopic predisposition modify the associations. Methods: In a population-based prospective cohort study among 3672 subjects, we measured maternal hemoglobin and hematocrit levels in early pregnancy, and lung function by spirometry and current asthma by questionnaire at age 10 years. Results: Higher maternal hematocrit levels, both continuously and categorized into clinical cut-offs, were associated with lower forced expiratory flow at 75% of forced vital capacity (FEF75) in children (Z-score (95%CI): −0.04 (−0.07, −0.01), per increase of 1 SDS in hematocrit level; Z-score (95%CI) difference: −0.11 (−0.20, −0.03) compared with normal hematocrit levels, respectively), taking lifestyle and socio-economic factors into account. Adverse pregnancy outcomes and atopic predisposition did not modify the results. No associations of maternal hemoglobin and hematocrit with current asthma were observed. Conclusion: Higher maternal hematocrit levels during pregnancy are associated with lower childhood lung function but not with risk of asthma. Adverse pregnancy outcomes and atopic predisposition do not modify these associations. Underlying mechanisms need to be further studied. |
| Databáze: | OpenAIRE |
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