Impact of the Receptor for Advanced Glycation End Products Genetic Polymorphisms on the Progression in Uterine Cervical Cancer
Autor: | Chun-Fang Hsu, Shun-Fa Yang, Soo-Cheen Ng, Chung-Yuan Lee, Po-Hui Wang, Yi-Hsuan Hsiao |
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Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty overall survival Single-nucleotide polymorphism Lower risk RAGE (receptor) 03 medical and health sciences 0302 clinical medicine Glycation single nucleotide polymorphism Internal medicine Genotype Parametrium medicine recurrence-free survival Receptor Cervical cancer business.industry medicine.disease RAGE 030104 developmental biology medicine.anatomical_structure 030211 gastroenterology & hepatology business uterine cervical cancer Research Paper |
Zdroj: | Journal of Cancer |
ISSN: | 1837-9664 |
Popis: | To date, few studies have explored the effects of single nucleotide polymorphisms (SNPs) of the receptor for advanced glycation end products (RAGE) in uterine cervical cancer. Therefore, we conducted this study to investigate the involvement of RAGE SNPs in cervical cancer. In total, 117 patients with cervical invasive cancer, 84 with precancerous lesions, and 320 normal women were recruited consecutively. Real-time polymerase chain reaction was used to examine the genotypic frequencies of RAGE SNPs. The results indicated that among the four RAGE SNPs, only the GT/TT genotype of rs184003 was distributed differently between patients with cervical neoplasias and the normal controls, with GG as a reference. Moreover, cervical cancer patients with genotypes TA/AA in rs1800624 exhibited a lower risk of parametrium invasion, moderate-to-poor cell differentiation, and pelvic lymph node metastasis. In conclusion, RAGE SNPs rs1800624 was associated with some clinicopathological variables in cervical cancer. |
Databáze: | OpenAIRE |
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