Effect of silver nanoparticles on healing of third-degree burns infected with Pseudomonas aeruginosa in laboratory mice
| Autor: | Sanaa Basher Kadhm, Haider F. Al-Saedi, Abbas Najee Balasm, Mukhallad Abdul Kareem Ramadhan |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0303 health sciences
silver nanoparticles General Veterinary Third-Degree Burn integumentary system Chemistry Pseudomonas aeruginosa Veterinary medicine infected burnssilver nanoparticles 02 engineering and technology 021001 nanoscience & nanotechnology medicine.disease_cause Silver nanoparticle skin healing Microbiology 03 medical and health sciences silver ointment SF600-1100 medicine skin burns 0210 nano-technology 030304 developmental biology infected burns |
| Zdroj: | Macedonian Veterinary Review, Vol 44, Iss 1, Pp 17-28 (2021) |
| ISSN: | 1857-7415 1409-7621 |
| Popis: | The treatment of full-thickness skin burn using nanomaterials is promising as a medical application reducing the risk of infection and severe dermal scarring. Therefore, this study aims to evaluate the effectiveness of nanomaterials, particularly 3% silver nanoparticles containing ointment (3% SNO), on the full-thickness skin burn of laboratory mice. A total number of 36 male mice were used, equally divided into three groups: negative control (not burned and not treated); positive control (+ve) (burned and treated with castor oil and white petroleum jelly); and SNO-treated group (burned and treated with 3% SNO). The skin of the animals’ back was shaved. A 2x0.5 cm metal plate was heated on a burner to burn the skin of the animals of positive control and SNO-treated groups. Pseudomonas aeruginosa bacterial suspension was applied to the burnt area. The application of SNO, as well as the mixture of white petroleum jelly and castor oil, was started after 6 hours of inducing burns and continued for 14 days (three times daily) in the respected groups. The SNO-treated group showed accelerated healing within 14 days demonstrated by re-epithelialization of the epidermal layer and proliferation of the fibroblasts in the dermal layer. Less healing evidence was observed in the +ve control group in the same period. In conclusion, to our knowledge, this is the first study that uses a 3% SNO formula and has found that it has a promising impact on the treatment of infected skin burns. |
| Databáze: | OpenAIRE |
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