Some histological aspects of amyloid polyneuropathy
| Autor: | Hanna Jedrzejowska |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Adult
Male Sural nerve Nerve Fibers Myelinated Pathology and Forensic Medicine law.invention Cellular and Molecular Neuroscience Sural Nerve law Medicine Humans Histological examination business.industry Peripheral Nervous System Diseases Anatomy Amyloidosis Axons Microscopy Electron Spinal Nerves nervous system Segmental demyelination Nerve Degeneration Amyloid polyneuropathy Neurology (clinical) Electron microscope business Axonal degeneration Demyelinating Diseases |
| Zdroj: | Acta neuropathologica. 37(2) |
| ISSN: | 0001-6322 |
| Popis: | Two sporadic cases of amyloid polyneuropathy with clinical features corresponding to the Portuguese type of this disease were studied. Histological examination of sural nerve demonstrated a marked loss of myelinated and unmyelinated fibres in the case 1 due to axonal degeneration, high content of fibers with segmental demyelination and the occurrence of several enlarged axons filled with the 10 nm filaments (so-called giant axons). In the case 2 there was total loss of unmyelinated axons and myelinated fibers were nearly completely lacking. In the development of changes in the myelinated fibers their direct compression by amyloid deposits seems to play an important role. It leads to the appearance of both axonal degeneration and segmental demyelination. The latter seems to be due to local compression and it may involved many fibers. In the light of observations reported by other authors the mechanism of changes developing in unmuelinated fibers is explained by the presence of changes in the cells of posterior root ganglia, however the question whether some abnormalities seen in unmyelinated axons could not be related to the pressure exerted by amyloid deposits directly to these fibers, remains open. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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