The induction of BDNF and c-fos mRNA in the hippocampal formation after febrile seizures
| Autor: | Park Kw, Eun Bl, Kim Yi, Myung Suk Kim, Rhyu Ij, Whang Kt, Rha Hk, Kim Ds, Young Hoon Kim, Yang-Hyeok Jo |
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| Rok vydání: | 2001 |
| Předmět: |
Male
medicine.medical_specialty Hippocampus In situ hybridization Hippocampal formation c-Fos Seizures Febrile Rats Sprague-Dawley Neurotrophic factors Internal medicine medicine Animals RNA Messenger Neurons Brain-derived neurotrophic factor Neuronal Plasticity biology Chemistry Brain-Derived Neurotrophic Factor General Neuroscience Dentate gyrus Hyperthermia Induced Rats Up-Regulation Endocrinology Gene Expression Regulation nervous system Dentate Gyrus biology.protein Proto-Oncogene Proteins c-fos Neuroscience Immediate early gene |
| Zdroj: | Neuroreport. 12:3243-3246 |
| ISSN: | 0959-4965 |
| DOI: | 10.1097/00001756-200110290-00020 |
| Popis: | In this study we investigated the expression of brain-derived neurotrophic factor (BDNF) and c-fos mRNA in the hippocampal formation after febrile seizures (FSs) with in situ hybridization histochemistry using riboprobes. The induction of BDNF mRNA was firstly observed in the dentate gyrus at 30 min after FSs. The expression in the dentate gyrus peaked at 3 h and returned to basal level at 24 h. It was also observed in the CA3 of hippocampus from 2 to 3 h. The induction of c-fos mRNA was observed in the dentate gyrus at 30 min and 1 h. These observations suggest that BDNF and c-fos are the genes whose expression can be altered by FSs and might be related to pathologic alterations after FSs. |
| Databáze: | OpenAIRE |
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