Stem Cell Therapy for Treatment of Ocular Disorders
| Autor: | Sakinah Syed, Murugan A. Munusamy, Padma Priya Sivan, Rukman Awang Hamat, Kadarkarai Murugan, Akihiro Umezawa, Akon Higuchi, Pooi Ling Mok, Abdullah A. Alarfaj, S. Suresh Kumar |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
lcsh:Internal medicine Pathology medicine.medical_specialty genetic structures business.industry medicine.medical_treatment Regeneration (biology) Clinical state Review Article Cell Biology Stem-cell therapy eye diseases 03 medical and health sciences 030104 developmental biology Visual function medicine Stem cell Progenitor cell lcsh:RC31-1245 business Molecular Biology Transcription factor Neuroscience |
| Zdroj: | Stem Cells International, Vol 2016 (2016) Stem Cells International |
| ISSN: | 1687-9678 1687-966X |
| Popis: | Sustenance of visual function is the ultimate focus of ophthalmologists. Failure of complete recovery of visual function and complications that follow conventional treatments have shifted search to a new form of therapy using stem cells. Stem cell progenitors play a major role in replenishing degenerated cells despite being present in low quantity and quiescence in our body. Unlike other tissues and cells, regeneration of new optic cells responsible for visual function is rarely observed. Understanding the transcription factors and genes responsible for optic cells development will assist scientists in formulating a strategy to activate and direct stem cells renewal and differentiation. We review the processes of human eye development and address the strategies that have been exploited in an effort to regain visual function in the preclinical and clinical state. The update of clinical findings of patients receiving stem cell treatment is also presented. |
| Databáze: | OpenAIRE |
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