Postoperative radiotherapy for mucoepidermoid carcinoma of the major salivary glands: long-term results of a single-institution experience
| Autor: | Sang-wook Lee, Geumju Park |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Multivariate analysis medicine.medical_treatment Postoperative radiotherapy Clinical Investigations Gastroenterology Major Salivary Gland Mucoepidermoid Carcinoma 03 medical and health sciences 0302 clinical medicine Mucoepidermoid carcinoma Internal medicine Major Salivary Gland medicine Radiology Nuclear Medicine and imaging 030223 otorhinolaryngology Salivary gland neoplasms Radiotherapy business.industry Hazard ratio Long term results medicine.disease Radiation therapy Oncology 030220 oncology & carcinogenesis Original Article business |
| Zdroj: | Radiation Oncology Journal |
| ISSN: | 2234-1900 |
| Popis: | PURPOSE This study aimed to evaluate the long-term survival outcomes and prognostic factors that affect the clinical outcomes of patients who underwent surgery and postoperative radiotherapy for major salivary gland mucoepidermoid carcinoma (MEC). MATERIALS AND METHODS We retrospectively reviewed the clinical data of 44 patients who underwent surgery followed by radiotherapy for primary MEC of the major salivary glands between 1991 and 2014. The median follow-up period was 9.8 years (range, 0.8 to 23.8 years). RESULTS The overall outcomes at 5 and 10 years were 81.5% and 78.0% for overall survival (OS), 86.2% and 83.4% for disease- free survival, 90.6% and 87.6% for locoregional recurrence-free survival, and both 90.5% for distant metastasis-free survival (DMFS). Histologic grade was the only independent predictor of OS (low vs. intermediate vs. high; hazard ratio = 3.699; p = 0.041) in multivariate analysis. A poorer survival was observed among patients with high-grade tumors compared with those with non-high- grade tumors (5-year OS, 37.5% vs. 91.7%, p < 0.001; 5-year DMFS, 46.9% vs. 100%, p < 0.001). CONCLUSION Surgery and postoperative radiotherapy resulted in excellent survival outcomes for patients with major salivary gland MEC. However, high-grade tumors contributed to poor DMFS and OS. Additional aggressive strategies for improving survival outcomes should be developed for high-grade MEC. |
| Databáze: | OpenAIRE |
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