Medium-dose ICS-containing FDCs reduce all-cause mortality in COPD patients: an in-depth analysis of dual and triple therapies
| Autor: | Luigino Calzetta, Maria Gabriella Matera, Paola Rogliani, Beatrice Ludovica Ritondo, Alfredo Chetta |
|---|---|
| Přispěvatelé: | Calzetta, L., Ritondo, B. L., Matera, M. G., Chetta, A., Rogliani, P. |
| Rok vydání: | 2021 |
| Předmět: |
Adrenergic beta-2 Receptor Agonist
Pulmonary and Respiratory Medicine medicine.medical_specialty Copd patients LABA Muscarinic Antagonists Pulmonary Disease Chronic Obstructive Administration Inhalation Settore MED/10 medicine COPD Humans Immunology and Allergy Intensive care medicine network meta-analysis Adrenergic beta-2 Receptor Agonists Bronchodilator Agent biology business.industry Nebulizers and Vaporizers LAMA Public Health Environmental and Occupational Health DUAL (cognitive architecture) Lama biology.organism_classification medicine.disease mortality Bronchodilator Agents network meta-analysi Muscarinic Antagonist ICS triple therapy Vital Status business Nebulizers and Vaporizer hormones hormone substitutes and hormone antagonists All cause mortality Human |
| Zdroj: | Expert Review of Respiratory Medicine. 16:357-365 |
| ISSN: | 1747-6356 1747-6348 |
| Popis: | Objectives: The recent publication of additional data retrieval for patients missing week 52 vital status in the original analyses of the ETHOS study provides the urgent need of updating previous network meta-analyses (NMA) to produce stronger evidence on mortality in patients receiving dual and triple FDCs according with the level of ICS dose. Methods: A NMA was performed to compare the effect of ICS/LABA/LAMA, ICS/LABA, and LABA/LAMA FDCs administered via the same inhaler device in COPD patients. The number need to treat (NNT) was also calculated. Results: When considering on-treatment all-cause of death (analyzed patients: 18,864), MD ICS/LABA/LAMA and MD ICS/LABA FDCs significantly reduced the risk of mortality vs. LABA/LAMA FDC (RR 0.59 95%CrI 0.35–0.97 and 0.61 95%CrI 0.38–0.99 respectively, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|