Ovarian metastasis risk factors in endometrial carcinoma: A systematic review and meta-analysis
Autor: | Jiangtao Fan, Sibang Chen, Hao Zeng, Mingyang Jiang, Siyi Liu, Xuzhi Liang |
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Rok vydání: | 2021 |
Předmět: |
Oncology
medicine.medical_specialty Ovary Metastasis Risk Factors Internal medicine medicine Carcinoma Humans Neoplasm Invasiveness Lymph node Pathological Neoplasm Staging Retrospective Studies Ovarian Neoplasms business.industry Incidence (epidemiology) Obstetrics and Gynecology medicine.disease Endometrial Neoplasms medicine.anatomical_structure Reproductive Medicine Meta-analysis Lymphatic Metastasis Female Lymph Nodes Ovarian cancer business |
Zdroj: | European journal of obstetrics, gynecology, and reproductive biology. 267 |
ISSN: | 1872-7654 |
Popis: | Objective To investigate the incidence of ovarian metastasis in endometrial carcinoma (EC) and analyze its risk factors and provide a theoretical basis for whether retention of the ovary in patients with EC. Methods A systematic search using synonyms of ‘ovarian cancer’ and ‘metastasis' was conducted in PubMed, Cochrane database, Embase, Google Scholar, and WOS database. Meta-analysis was performed on 7 included studies, comprising 4281 clinical-stage I-IV EC patients. Studies were assessed using the Newcastle–Ottawa Scale (NOS) criteria. Odds risks (OR) and 95% confidence intervals (CI) were calculated using an inverse variance weighted random-effects model. Results The ovarian metastasis risk of EC was significantly higher for patients with myometrial invasion >1/2 (OR = 18.19, 95% CI 5.34 to 61.96 compared to myometrial invasion ≤1/2), any pelvic lymph node invasion (PLNI) (OR = 5.41, 95% CI 2.60–10.97 compared to without PLNI), G3 pathological grade (OR = 2.66, 95%CI 1.35–5.24 compared to G1-G2), non-endometrioid pathological type (OR = 6.46, 95% CI 3.25 to 12.83 compared to endometrioid), lymphatic vascular space invasion (LVSI) (OR = 6.46, 95% CI 3.25 to 12.83 compare to without LVSI), age >45 (OR = 2.01, 95% CI 0.29 to 14.11 compared to age ≤45), and cervical invasion (OR = 4.12, 95% CI 1.87 to 9.08 compared to without cervical invasion). Conclusion About 4.95% of EC patients develop ovarian metastasis. Age >45, myometrial invasion >1/2, cervical invasion, PLNI, pathological type, G3 pathological grade, and LVSI were the high-risk factors for ovarian metastasis of EC. Ovarian preservation should be carefully selected for patients with EC, and preoperative and intraoperative evaluations should be entirely performed. |
Databáze: | OpenAIRE |
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