ANTI-B CELL LYMPHOCYTOTOXIC ANTIBODIES IN KIDNEY TRANSPLANT RECIPIENTS
| Autor: | C. Bracq, V. Lepage, M. C. Rudloff, Jean Dausset, Jean Claude Gluckman, Duboust A, J. Bedrossian, T. Nebout |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Cytotoxicity
Immunologic Graft Rejection Cell Kidney transplant Antibodies hemic and lymphatic diseases Cadaver Humans Transplantation Homologous Medicine Lymphocytes B cell B-Lymphocytes Transplantation biology business.industry Graft Survival hemic and immune systems Serum samples Kidney Transplantation Blood lymphocyte medicine.anatomical_structure Cell culture Immunology biology.protein Female Graft survival Antibody business |
| Zdroj: | Transplantation. 25:255-258 |
| ISSN: | 0041-1337 |
| DOI: | 10.1097/00007890-197805000-00007 |
| Popis: | Serial serum samples from 47 renal allotransplant recipients were screened for antiperipheral blood lymphocyte, anti-B cell, and anti-Daudi cell line antibodies. Various associations of these antibodies were observed in 28 patients. Anti-Daudi did not correlate with graft survival, whereas anti-B, although they were often associated with anti-peripheral blood lymphocyte antibodies, showed the strongest correlation with chronic rejection (P = 0.00002). However anti-B cytotoxicity preceded or was concurrent with the onset of chronic rejection in only 53% of the cases. Antibodies were absent in six of nine patients with irreversible acute rejection, but they usually appeared after transplant nephrectomy. These findings suggest that anti-B cell antibodies may play a role in the rejection process. In 15 of 17 recipients (88%), anti-B cell antibodies occurred during the first trimester after transplantation. These patients showed 20% 1-year graft survival compared with 68% in those without antibodies at that time (P less than 0.005). |
| Databáze: | OpenAIRE |
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