Serum Lycopene Levels in Patients with Diabetic Retinopathy
| Autor: | Chi-Cheng Ma, Xiu-Zhen Lu, Li Chen, Zhen-Zuo Li |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Antioxidant medicine.medical_treatment Type 2 diabetes medicine.disease_cause Gastroenterology Pathogenesis 03 medical and health sciences chemistry.chemical_compound Lycopene 0302 clinical medicine Internal medicine Diabetes mellitus medicine Humans Chromatography High Pressure Liquid Diabetic Retinopathy business.industry General Medicine Diabetic retinopathy Middle Aged Prognosis medicine.disease Carotenoids Oxidative Stress Ophthalmology 030104 developmental biology Diabetes Mellitus Type 2 chemistry Disease Progression 030221 ophthalmology & optometry Female business Biomarkers Oxidative stress Retinopathy |
| Zdroj: | European Journal of Ophthalmology. 20:719-723 |
| ISSN: | 1724-6016 1120-6721 |
| DOI: | 10.1177/112067211002000412 |
| Popis: | Purpose. Accumulating evidence indicates that oxidative stress may play an important role in the pathogenesis of type 2 diabetes and its complications. Lycopene, a very potent antioxidant of carotenoids, has received considerable scientific interest in recent years for its potential role in the prevention of oxidative stress-related chronic diseases. This study was undertaken to investigate whether the serum levels of lycopene are altered between type 2 diabetic patients with and without diabetic retinopathy. Methods. A total of 71 patients with type 2 diabetes were analyzed and compared with 23 nondiabetic healthy controls. Serum lycopene concentrations were assayed using high-performance liquid chromatography. Results. Lycopene level was found to be significantly lower in diabetic patients than in controls (p=0.021). In the diabetic group, subjects with proliferative diabetic retinopathy had significantly lower lycopene levels than subjects without diabetic retinopathy or with nonproliferative diabetic retinopathy. In the analysis of correlations, hemoglobin A1c were negatively correlated with lycopene (r=–0.345, p=0.007) after multivariate adjustment. A stepwise linear multiple regression model revealed that age and hemoglobin A1c were significant determinants of lycopene. Conclusions. Our findings show that measuring serum lycopene is a novel convenient method for evaluating oxidative damage. Diabetic patients, especially those with advanced diabetic retinopathy, had significantly lower serum lycopene levels; this suggests that lycopene may be helpful for the diagnosis, severity, and therapeutic evaluation of diabetic retinopathy. |
| Databáze: | OpenAIRE |
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