Peripheral serotonin measures in prepubertal psychiatric inpatients and normal children: associations with suicidal behavior and its risk factors
| Autor: | George M. Anderson, P. Anne McBride, Cynthia R. Pfeffer, Leonard Fensterheim, Tatsuyuki Kakuma, Vadim Khait |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Blood Platelets
Male medicine.medical_specialty Serotonin Platelet Aggregation Poison control Suicide Attempted Risk Factors medicine Humans Risk factor Psychiatry Child Suicidal ideation Biological Psychiatry Whole blood Psychiatric Status Rating Scales Inpatients Suicide attempt Mood Disorders Mental Disorders Tryptophan Suicide Mood El Niño Attention Deficit and Disruptive Behavior Disorders Receptors Serotonin Female medicine.symptom Psychology |
| Zdroj: | Biological psychiatry. 44(7) |
| ISSN: | 0006-3223 |
| Popis: | Background: This study reports relationships between suicidal behavior and its risk factors in prepubertal children and whole blood and platelet serotonin-related measures. Methods: Seventy-five prepubertal psychiatric inpatients including 23 (30.7%) nonsuicidal, 32 (42.7%) with suicidal ideation, and 20 (26.6%) with a suicide attempt were compared to 35 normal prepubertal controls with regard to platelet serotonin content, serotonin-amplified platelet aggregation, and whole blood tryptophan. Results: Mean whole blood tryptophan content was significantly lower among inpatient children with a recent suicide attempt than among normal controls or inpatients with suicidal ideation ( F = 3.94, df=3.54, p ≤ .01). Inpatient children with a mood disorder had significantly higher platelet serotonin content than inpatients without a mood disorder ( F = 3.86, df=2,80, p ≤ .03). Racial/ethnic differences were also observed for inpatients and normal controls, with whites having significantly lower levels of platelet serotonin (expressed as ng/mL blood or ng/10 9 platelets) than blacks or Latinos. Blacks had significantly higher levels of whole blood tryptophan than other racial/ethnic groups. Conclusions: The results suggest that whole blood tryptophan and platelet serotonin content should be studied for their predictive validity as risk factors for suicidal behavior in youth while controlling for racial/ethnic differences. |
| Databáze: | OpenAIRE |
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