Optical Control of Small Molecule-Induced Protein Degradation
| Autor: | Alexander Deiters, Kristie Darrah, Yuta Naro |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Proteolysis
Ubiquitin-Protein Ligases Protein degradation 010402 general chemistry Ligands 01 natural sciences Biochemistry Catalysis Article Small Molecule Libraries Colloid and Surface Chemistry Ubiquitin medicine medicine.diagnostic_test biology Extramural Chemistry Cereblon Ubiquitination General Chemistry Small molecule 0104 chemical sciences Optical control biology.protein Biophysics |
| Zdroj: | J Am Chem Soc |
| DOI: | 10.26434/chemrxiv.8216714.v1 |
| Popis: | As an emerging approach to protein perturbation, small molecule-induced protein degradation has gained significant attention as both a chemical tool and a potential therapeutic. To enable discrete control over its function, we have developed a broadly applicable approach for the optical activation of small molecule-induced protein degradation. By installing two different photolabile protecting groups, so-called caging groups, onto two different ligands recruiting Von Hippel-Lindau (VHL) and cereblon (CRBN) E3 ubiquitin ligases, our strategy enables light-triggered protein degradation for any small molecule warhead. |
| Databáze: | OpenAIRE |
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