Baseline acetylcholinesterase activity and serotonin plasma levels are not associated with delirium in critically ill patients
| Autor: | Francieli Vuolo, Alexandra I. Zugno, Cristiane Ritter, Larissa Constantino, Felipe Dal-Pizzol, Jorge I. F. Salluh, Marcio Soares, Francieli Zanatta, Cristiane Damiani Tomasi |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Serotonin/drug effects Serotonin medicine.medical_specialty Critical Illness Critical Care and Intensive Care Medicine behavioral disciplines and activities law.invention Cohort Studies Sepsis chemistry.chemical_compound law mental disorders medicine Humans Prospective Studies Intensive care medicine Prospective cohort study Aged Aged 80 and over Coma Intensive care units business.industry Delirium General Medicine Middle Aged medicine.disease Acetylcholinesterase/drug effects Acetylcholinesterase Intensive care unit chemistry Anesthesia Original Article Female medicine.symptom business Biomarkers Cohort study |
| Zdroj: | Revista Brasileira de Terapia Intensiva |
| ISSN: | 0103-507X |
| Popis: | Objective: The aim of this study was to investigate whether plasma serotonin levels or acetylcholinesterase activities determined upon intensive care unit admission could predict the occurrence of acute brain dysfunction in intensive care unit patients. Methods: A prospective cohort study was conducted with a sample of 77 non-consecutive patients observed between May 2009 and September 2010. Delirium was determined using the Confusion Assessment Method for the Intensive Care Unit tool, and the acetylcholinesterase and serotonin measurements were determined from blood samples collected up to a maximum of 24 h after the admission of the patient to the intensive care unit. Results: In the present study, 38 (49.6%) patients developed delirium during their intensive care unit stays. Neither serum acetylcholinesterase activity nor serotonin level was independently associated with delirium. No significant correlations of acetylcholinesterase activity or serotonin level with delirium/coma-free days were observed, but in the patients who developed delirium, there was a strong negative correlation between the acetylcholinesterase level and the number of delirium/coma-free days, indicating that higher acetylcholinesterase levels are associated with fewer days alive without delirium or coma. No associations were found between the biomarkers and mortality. Conclusions: Neither serum acetylcholinesterase activity nor serotonin level was associated with delirium or acute brain dysfunction in critically ill patients. Sepsis did not modify these relationships. |
| Databáze: | OpenAIRE |
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