The role of Omega-3 and Omega-9 fatty acids for the treatment of neuropathic pain after neurotrauma
| Autor: | Julian Taylor, Iriana Galán-Arriero, Carlos Goicoechea, Diego Serrano-Muñoz, Julio Gómez-Soriano, Ana Velasco, Gerardo Ávila-Martín |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Biophysics Oleic Acids Hyperreflexia Pharmacology Biochemistry Fatty Acids Monounsaturated 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Peripheral Nerve Injuries Fatty Acids Omega-3 medicine Humans Spinal cord injury Spinal Cord Injuries Neuroinflammation chemistry.chemical_classification Cell Biology medicine.disease Eicosapentaenoic acid Oleic acid 030104 developmental biology chemistry Peripheral nerve injury Neuropathic pain Neuralgia lipids (amino acids peptides and proteins) medicine.symptom 030217 neurology & neurosurgery Oleic Acid Polyunsaturated fatty acid |
| Zdroj: | Biochimica et Biophysica Acta (BBA) - Biomembranes. 1859:1629-1635 |
| ISSN: | 0005-2736 |
| Popis: | Omega-3 polyunsaturated fatty acids (PUFAs), such as docosaexaenoic acid (DHA) and eicosapentaenoic acid (EPA), mediate neuroactive effects in experimental models of traumatic peripheral nerve and spinal cord injury. Cellular mechanisms of PUFAs include reduced neuroinflammation and oxidative stress, enhanced neurotrophic support, and activation of cell survival pathways. Bioactive Omega-9 monounsaturated fatty acids, such as oleic acid (OA) and 2-hydroxy oleic acid (2-OHOA), also show therapeutic effects in neurotrauma models. These FAs reduces noxious hyperreflexia and pain-related anxiety behavior following peripheral nerve injury and improves sensorimotor function following spinal cord injury (SCI), including facilitation of descending inhibitory antinociception. The relative safe profile of neuroactive fatty acids (FAs) holds promise for the future clinical development of these molecules as analgesic agents. This article is part of a Special Issue entitled: Membrane Lipid Therapy: Drugs Targeting Biomembranes edited by Pablo V. Escribá. |
| Databáze: | OpenAIRE |
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