EXPANDED CLINICAL SPECTRUM OF MULTIPLE EVANESCENT WHITE DOT SYNDROME WITH MULTIMODAL IMAGING

Autor: Brandon J. Lujan, Lawrence A. Yannuzzi, Sarah Mrejen, Marion R. Munk, Thomas A. Albini, Lee M. Jampol, Eduardo Cunha de Souza, Marcela Marsiglia, K. Bailey Freund, Emmett T. Cunningham, Naomi Goldberg, Catherine Français, Richard B Rosen, Alain Gaudric, Su-Quin Yu, Roberto Gallego-Pinazo
Rok vydání: 2015
Předmět:
Male
retina
Pathology
Multiple evanescent white dot syndrome
genetic structures
multimodal imaging
Retinal Pigment Epithelium
autofluorescence
Multimodal Imaging
Cohort Studies
0302 clinical medicine
fluorescein angiography
Photography
Medicine
Fluorescein Angiography
610 Medicine & health
medicine.diagnostic_test
Optical Imaging
General Medicine
Middle Aged
Fluorescein angiography
medicine.anatomical_structure
uveitis
posterior uveitis
Female
Tomography
indocyanine green angiography
Tomography
Optical Coherence
Adult
medicine.medical_specialty
Adolescent
multiple evanescent white dot syndrome
03 medical and health sciences
Young Adult
Optical coherence tomography
Retinal Diseases
Ophthalmology
Humans
Outer nuclear layer
Retrospective Studies
Retina
optical coherence tomography
business.industry
Fundus photography
medicine.disease
MEWDS
eye diseases
Autofluorescence
030221 ophthalmology & optometry
sense organs
business
030217 neurology & neurosurgery
Zdroj: RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
Marsiglia, M; Gallego-Pinazo, R; Cunha de Souza, E; Munk, Marion; Mrejen, S; Cunningham, ET; Lujan, BJ; Goldberg, NR; Albini, TA; Gaudric, A; Francais, C; Rosen, R; Freund, BK; Jampol, LM; Yannuzzi, LA (2016). Expanded Clinical Spectrum of Multiple Evanescent White Dot Syndrome with Multimodal Imaging. Retina-the journal of retinal and vitreous diseases, 36(1), pp. 64-74. Lippincott, Williams & Wilkins 10.1097/IAE.0000000000000685
ISSN: 1539-2864
0275-004X
DOI: 10.1097/IAE.0000000000000685
Popis: PURPOSE: To evaluate and characterize multiple evanescent white dot syndrome abnormalities with modern multimodal imaging modalities. METHODS: This retrospective cohort study evaluated fundus photography, fluorescein angiography, indocyanine green angiography, optical coherence tomography, enhanced depth imaging optical coherence tomography, short-wavelength autofluorescence, and near-infrared autofluorescence. RESULTS: Thirty-four multiple evanescent white dot syndrome patients with mean age of 28.7 years were studied (range, 14-49 years). Twenty-six patients were women, and eight were men. Initial mean visual acuity was 0.41 logMAR. Final mean visual acuity was 0.03 logMAR. Fluorescein angiography shows a variable number of mid retinal early fluorescent dots distributed in a wreathlike pattern, which correlate to fundus photography, fundus autofluorescence, and indocyanine green angiography. Indocyanine green angiography imaging shows the dots and also hypofluorescent, deeper, and larger spots, which are occasionally confluent, demonstrating a large plaque of deep retinal hypofluorescence. Optical coherence tomography imaging shows multifocal debris centered at and around the ellipsoid layer, corresponding to the location of spots seen with photography, indocyanine green angiography, and fluorescein angiography. Protrusions of the hyperreflectant material from the ellipsoid layer toward the outer nuclear layer correspond to the location of dots seen with photography, indocyanine green angiography, and fluorescein angiography. CONCLUSION: Multimodal imaging analysis of the retina in patients with multiple evanescent white dot syndrome shows additional features that may help in the diagnosis of the disease and in further understanding its etiology. Multiple evanescent white dot syndrome is predominantly a disease of the outer retina, centered at the ellipsoid zone, but also involving the interdigitation zone and the outer nuclear layer.
Databáze: OpenAIRE
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