Lymph vessels: the forgotten second circulation in health and disease
| Autor: | Ulrik Baandrup, Ivana Kholová, Lukasz A. Adamczyk, Kristiana Gordon, Niklas Telinius, Patrick J. Gallagher, Allard C. van der Wal, Lorine B. Meijer-Jorna |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty government.form_of_government Vesicular Transport Proteins Vascular malformation Metastasis Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine medicine Genetics Animals Humans Lymphedema Lymphangiogenesis Molecular Biology Lymphatic Vessels Lymph vessels Homeodomain Proteins business.industry General Medicine Cell Biology medicine.disease Atherosclerosis Immunohistochemistry Lymphovascular Review and Perspectives Lymphatic Endothelium Circulation 030104 developmental biology Lymphatic system 030220 oncology & carcinogenesis Circulatory system Immunology government Lymph Angiogenesis Endothelium Lymphatic Vascular pathology business Biomarkers |
| Zdroj: | Virchows Archiv Adamczyk, L A, Gordon, K, Kholová, I, Meijer-Jorna, L B, Telinius, N, Gallagher, P J, van der Wal, A C & Baandrup, U 2016, ' Lymph vessels : the forgotten second circulation in health and disease ', Virchows Archiv, vol. 469, no. 1, pp. 3-17 . https://doi.org/10.1007/s00428-016-1945-6 |
| ISSN: | 1432-2307 |
| Popis: | The lymphatic circulation is still a somewhat forgotten part of the circulatory system. Despite this, novel insights in lymph angiogenesis in health and disease, application of immune markers for lymphatic growth and differentiation and also the introduction of new imaging techniques to visualize the lymphatic circulation have improved our understanding of lymphatic function in both health and disease, especially in the last decade. These achievements yield better understanding of the various manifestations of lymph oedemas and malformations, and also the patterns of lymphovascular spread of cancers. Immune markers that recognize lymphatic endothelium antigens, such as podoplanin, LYVE-1 and Prox-1, can be successfully applied in diagnostic pathology and have revealed (at least partial) lymphatic differentiation in many types of vascular lesions. Electronic supplementary material The online version of this article (doi:10.1007/s00428-016-1945-6) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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