Multi-institutional retrospective analysis of ultrahypofractionated radiotherapy for Japanese prostate cancer patients

Autor: Katsumasa Nakamura, Motoi Watanabe, Eiichi Mizuno, Masashi Taka, Hiroaki Kobayashi, Takahisa Eriguchi, Hisato Nagano, Hideyasu Tsumura, Hajime Imada, Hiromichi Ishiyama, Koji Inaba
Rok vydání: 2021
Předmět:
Biochemical recurrence
Male
medicine.medical_specialty
Science
medicine.medical_treatment
Urogenital System
Urological cancer
Adenocarcinoma
Radiosurgery
Effective dose (radiation)
Gastroenterology
Article
030218 nuclear medicine & medical imaging
Androgen deprivation therapy
03 medical and health sciences
Prostate cancer
0302 clinical medicine
Japan
Internal medicine
Medicine
Humans
Risk factor
Radiation Injuries
Aged
Retrospective Studies
Cancer
Aged
80 and over
Multidisciplinary
business.industry
Genitourinary system
Prostatic Neoplasms
Androgen Antagonists
Middle Aged
Prostate-Specific Antigen
medicine.disease
Combined Modality Therapy
Neoadjuvant Therapy
Progression-Free Survival
Radiation therapy
030220 oncology & carcinogenesis
Radiation Dose Hypofractionation
business
Follow-Up Studies
Zdroj: Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
ISSN: 2045-2322
Popis: To report outcomes and risk factors of ultrahypofractionated (UHF) radiotherapy for Japanese prostate cancer patients. This multi-institutional retrospective analysis comprised 259 patients with localized prostate cancer from 6 hospitals. A total dose of 35–36 Gy in 4–5 fractions was prescribed for sequential or alternate-day administration. Biochemical failure was defined according to the Phoenix ASTRO consensus. Toxicities were assessed using National Cancer Institute Common Toxicity Criteria version 4. Tumor control and toxicity rates were analyzed by competing risk frames. Median follow-up duration was 32 months (range 22–97 months). 2- and 3-year biochemical control rates were 97.7% and 96.4%, respectively. Initial prostate-specific antigen (p
Databáze: OpenAIRE
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