Bcl-2 protein expression in acute and chronic hepatitis, cirrhosis and hepatocellular carcinoma
Autor: | Ch. Vourlakou, N. Manolaki, Lydia Nakopoulou, G. Michalopoulos, K. Stefanaki, Hariklia Gakiopoulou |
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Rok vydání: | 1999 |
Předmět: |
Liver Cirrhosis
medicine.medical_specialty Carcinoma Hepatocellular Cirrhosis Biopsy Population Intrahepatic bile ducts Apoptosis Gastroenterology Pathology and Forensic Medicine Immunoenzyme Techniques Hepatitis B Chronic Internal medicine medicine Humans Aspartate Aminotransferases education education.field_of_study business.industry Liver Neoplasms Alanine Transaminase Cell Biology Hepatitis C Chronic medicine.disease Embryonic stem cell Proto-Oncogene Proteins c-bcl-2 Cytoplasm Hepatocellular carcinoma Acute Disease Cancer research Bile Ducts business Viral hepatitis |
Zdroj: | Pathology - Research and Practice. 195:19-24 |
ISSN: | 0344-0338 |
DOI: | 10.1016/s0344-0338(99)80089-2 |
Popis: | Summary Bcl-2 protein blocks apoptosis and is involved in human intrahepatic bile-duct development. Formalinfixed, paraffin-embedded archival tissue from 42 HBV and HCV hepatitis [20 acute AH, 22 chronic hepatitis (CH)], 12 active cirrhosis (CR) and 20 hepatocellular carcinoma (HCC) was immunostained for bcl-2 protein. In all cases, bcl-2 protein was detected in portal and intralobular lymphocytes but not in hepatocytes or Kupffer cells. Bcl-2 was positive in the cytoplasm of small portal bile ducts of chronic hepatitis, while it was strongly expressed in newly formed bile-ductules of the limiting plate, mainly in CH with marked activity and CR. Bcl-2 was detected in small bile ducts in only one case of acute hepatitis and was not detected in any case of HCC. Bcl-2 seems to be involved in the regulation of growth and apoptosis of cholangiolar cells. Its expression in small bile ducts and in newly-formed ductules especially in CH with marked activity and CR, implies that the embryonic model of intrahepatic bile duct development may be recapitulated in chronic hepatic disease. Moreover, it supports evidence for the existence of the controversial long-lived stem population in the liver. Bcl-2 does not seem to be involved in hepatocarcinogenesis. |
Databáze: | OpenAIRE |
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