Intentional overdose of the novel anti-epileptic drug eslicarbazepine presenting with recurrent seizures and ventricular dysrhythmias
Autor: | Jesse Thompson, James D Powell, Daniel H Ovakim |
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Rok vydání: | 2017 |
Předmět: |
Adolescent
Defibrillation medicine.medical_treatment Sedation Lorazepam 030226 pharmacology & pharmacy Hypoxemia 03 medical and health sciences 0302 clinical medicine Dibenzazepines Renal Dialysis Seizures Medicine Humans Cardiopulmonary resuscitation Hypoxia business.industry Emergency department Heart Arrest Anticonvulsant Anesthesia Emergency Medicine Tachycardia Ventricular Anticonvulsants Female Hemodialysis medicine.symptom Drug Overdose business Propofol 030217 neurology & neurosurgery medicine.drug |
Zdroj: | CJEM. 20(S2) |
ISSN: | 1481-8043 |
Popis: | Eslicarbazepine is a novel anti-epileptic agent indicated for the treatment of partial-onset seizures. We present the case of an 18 year old female that presented to the Emergency Department four hours after a reported intentional ingestion of an estimated 5600 mg of eslicarbazepine. Although initially hemodynamically stable and neurologically normal, shortly after arrival she developed confusion, rigidity and clonus, followed by recurrent seizures, hypoxemia and cardiac arrest which responded to cardiopulmonary resuscitation and wide complex tachycardia requiring defibrillation. Treatment for refractory seizures included benzodiazepines and eventual intubation and sedation with propofol. Cardiac toxicity responded to sodium bicarbonate. In addition, empiric hemodialysis was performed. In this case report, we discuss the successful management of the first reported overdose of eslicarbazepine using supportive care and hemodialysis. |
Databáze: | OpenAIRE |
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