Multivalent NHS-activated acrylates for orthogonal site-selective functionalisation of peptides at cysteine residues

Autor:	Mariama Djaló, Maria J. S. A. Silva, Hélio Faustino, Sandra N. Pinto, Ricardo Mendonça, Pedro M. P. Gois
Rok vydání:	2022
Předmět:	Acrylates Materials Chemistry Metals and Alloys Ceramics and Composites General Chemistry Cysteine Peptides Catalysis State Medicine Surfaces Coatings and Films Electronic Optical and Magnetic Materials
Zdroj:	Chemical communications (Cambridge, England). 58(57)
ISSN:	1364-548X
Popis:	The site-selective chemical appendage of multiple functionalities on a native peptide backbone is a highly demanding and complex tool of modern chemical biology. Here, novel NHS-activated acrylates were designed to hold various payloads in a single bioconjugation handle that is able to site-selectively and orthogonally target the
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aad3b1716d787d24904cafa8d55417d2 https://pubmed.ncbi.nlm.nih.gov/35758206 Zobrazit plný text záznamu