Development of Zoledronic Acid Containing Biomaterials for Enhanced Guided Bone Regeneration
| Autor: | Mehmet Salih Deveci, Mete Toptaş, Umut Can Oz, Burcu Devrim, Elif Ünsal, Asuman Bozkir, Hasan Bilgili, Berrin Küçüktürkmen, Ongun Mehmet Saka |
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| Rok vydání: | 2021 |
| Předmět: |
Bone Regeneration
Pharmaceutical Science Lamellar bone Connective tissue Biocompatible Materials 02 engineering and technology Zoledronic Acid 030226 pharmacology & pharmacy Bone and Bones 03 medical and health sciences 0302 clinical medicine Fibrosis medicine Animals Bone regeneration Chemistry Biomaterial Membranes Artificial Poloxamer 021001 nanoscience & nanotechnology medicine.disease Epithelium medicine.anatomical_structure Zoledronic acid Female Rabbits 0210 nano-technology Biomedical engineering medicine.drug |
| Zdroj: | Journal of Pharmaceutical Sciences. 110:3200-3207 |
| ISSN: | 0022-3549 |
| DOI: | 10.1016/j.xphs.2021.05.002 |
| Popis: | In recent years, biomaterial-based treatments, also called guided bone regeneration (GBR), which aim to establish a bone regeneration site and prevent the migration of gingival connective tissue and / or peripheral epithelium through the defective area during periodontal surgical procedures have come to the fore. In this report, we have developed a nanoparticle bearing thermosensitive in situ gel formulation of Pluronic F127 and poly(D,L-lactic acid) based membrane to reveal their utilization at GBR by in-vivo applications. In addition, the encouragement of the bone formation in defect area via inhibition of osteoclastic activity is intended by fabrication these biodegradable biomaterials at a lowered Zoledronic Acid (ZA) dose. Both of the developed materials remained stable under specified stability conditions (25 degrees C, 6 months) and provided the extended release profile of ZA. The in-vivo efficacy of nanoparticle bearing in situ gel formulation, membrane formulation and simultaneous application for guided bone regeneration was investigated in New Zealand female rabbits with a critical size defect of 0.5 pound 0.5 cm in the tibia bone for eight weeks. Based on the histopathological findings, lamellar bone and primarily woven bone formations were observed after 8 weeks of post-implantation of both formulations, while fibrosis was detected only in the untreated group. Lamellar bone growth was remarkably achieved just four weeks after the simultaneous application of formulations. Consequently, the simultaneous application of ZA-membrane and ZA-nanoparticles loaded in-situ gel formulations offers enhanced and faster GBR therapy alternatives. (c) 2021 American Pharmacists Association. Published by Elsevier Inc. All rights reserved. |
| Databáze: | OpenAIRE |
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