Ninety-six-hour wireless oesophageal pH monitoring following proton pump inhibitor administration in NERD patients
| Autor: | Fernando Rizzello, Veronica Gabusi, Paolo Gionchetti, Giuseppina Liguori, Ramona Brugnera, Carlo Calabrese, Giulia Straforini, G. Di Febo |
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| Přispěvatelé: | C. Calabrese, G. Liguori, V. Gabusi, P. Gionchetti, F. Rizzello, G. Straforini, R. Brugnera, G. Di Febo |
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male medicine.medical_specialty Esophageal pH Monitoring medicine.drug_class Nerd Lansoprazole Proton-pump inhibitor Gastroenterology 2-Pyridinylmethylsulfinylbenzimidazoles Internal medicine Humans Medicine Pharmacology (medical) Dosing Pantoprazole Omeprazole Hepatology medicine.diagnostic_test business.industry Reflux Proton Pump Inhibitors Middle Aged Anti-Ulcer Agents Treatment Outcome Gastroesophageal Reflux Female business Esophageal pH monitoring medicine.drug |
| Popis: | Summary Background Comparative studies of proton pump inhibitors (PPIs) have revealed that acid reflux is influenced by PPI treatment, formulations and dosing regimens. Wireless pH capsules have circumvented some of the limitations of conventional catheter-based pH testing with the additional advantage of 96-h recording periods. Aim To clarify the effectiveness of intra-oesophageal acid suppression by omeprazole, pantoprazole and lansoprazole in non-erosive reflux disease patients through a 4-day monitoring of oesophageal pH and related symptoms. Methods Twenty-four patients with typical symptoms of gastro-oesophageal reflux disease were enrolled and administered upper endoscopy and placement of a wireless pH capsule. Patients randomly received omeprazole, pantoprazole or lansoprazole for 3 days after the first 24 h. Symptom–reflux associations were expressed using the symptom index (SI). Results All patients completed the study. Significant decrease in acid exposure occurred on day 2 and in each successive day in all groups. Pantoprazole and omeprazole are more effective than lansoprazole at inducing a normalization of intra-oesophageal acid exposure at days 2 and 3. Significant reduction in SI at day 2 was observed. Conclusions Four-day ambulatory oesophageal pH monitoring is feasible and safe. Omeprazole, pantoprazole and lansoprazole have an equivalent potency for normalizing intra-oesophageal acid exposure after 3 days of treatment in non-erosive reflux disease patients. |
| Databáze: | OpenAIRE |
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