The assay of laminin fragments in serum and urine as an indicator of renal damage induced by toxins
| Autor: | A. D. R. Mackie, Enrico Bergamaschi, S. A. Taylor, Innocente Franchini, E. Crutcher, R. G. Price |
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| Jazyk: | angličtina |
| Rok vydání: | 1995 |
| Předmět: |
Adult
Male medicine.medical_specialty Tetrachloroethylene Urinary system Urine Toxicology Excretion Laminin Internal medicine Diabetes mellitus Occupational Exposure Acetylglucosaminidase medicine Humans Diabetic Nephropathies chemistry.chemical_classification Kidney biology Chemistry General Medicine Middle Aged medicine.disease Endocrinology medicine.anatomical_structure Enzyme Toxicity biology.protein Female Kidney Diseases |
| Popis: | An ELISA procedure for the assay of laminin fragments in serum and urine is described. Samples from solvent-exposed workers and diabetic patients were studied. In cohorts exposed to perchloroethylene serum and urine laminin fragments were elevated but the urinary N-acetyl-β- d -glucosaminidase (NAG) was unaffected. The data indicate that the urinary assay may be more specific for renal damage than the serum method. Differences in the excretion of NAG and urinary laminin fragments were observed in the diabetic groups suggesting that the excretion of these two components reflects different stages of severity of the disease. |
| Databáze: | OpenAIRE |
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