RNA-modifying proteins as anticancer drug targets
| Autor: | P. Ann Boriack-Sjodin, Robert A. Copeland, Scott Ribich |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Pharmacology RNA Stability Chemistry RNA Translation (biology) Antineoplastic Agents General Medicine Computational biology Methylation 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology Epitranscriptomics Neoplasms Drug Discovery Animals Humans MRNA methylation RNA Messenger DNA Function (biology) Macromolecule |
| Zdroj: | Nature reviews. Drug discovery. 17(6) |
| ISSN: | 1474-1784 |
| Popis: | All major biological macromolecules (DNA, RNA, proteins and lipids) undergo enzyme-catalysed covalent modifications that impact their structure, function and stability. A variety of covalent modifications of RNA have been identified and demonstrated to affect RNA stability and translation to proteins; these mechanisms of translational control have been termed epitranscriptomics. Emerging data suggest that some epitranscriptomic mechanisms are altered in human cancers as well as other human diseases. In this Review, we examine the current understanding of RNA modifications with a focus on mRNA methylation, highlight their possible roles in specific cancer indications and discuss the emerging potential of RNA-modifying proteins as therapeutic targets. |
| Databáze: | OpenAIRE |
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