The regulation of energy balance by the central nervous system
| Autor: | Randy J. Seeley, Karine Proulx |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Central Nervous System
Leptin medicine.medical_specialty Pro-Opiomelanocortin Peptide Hormones Hypothalamus Energy homeostasis Neurochemical medicine Humans Insulin Neuropeptide Y Obesity Psychiatry Glucocorticoids business.industry Body Weight Caloric theory medicine.disease Comorbidity Mental health Ghrelin Psychiatry and Mental health Mood business Energy Metabolism Neuroscience Signal Transduction |
| Zdroj: | The Psychiatric clinics of North America. 28(1) |
| ISSN: | 0193-953X |
| Popis: | Obesity is the result of a sustained mismatch in which caloric intake exceeds caloric expenditure. In fact, despite what the growing obesity epidemic might argue, under most circumstances the energy balance equation is regulated with tremendous precision over time. Such profound accuracy implies that body weight, or more precisely body adipose mass, is a biologically regulated variable, and that evolution has selected for mechanisms by which caloric intake can be matched to caloric expenditure. Although obesity is increasingly common, it is even more common in those suffering from serious psychiatric disorders [1]. Although many of the drugs used to treat psychiatric disorders can produce weight gain, it would appear that the relationship between obesity and mental health problems exists independent of medication. Epidemiological studies have demonstrated that mood and binge-eating disorders coexist with obesity in a significant minority of individuals [2,3]. The comorbidity of psychiatric disorders with obesity suggests the existence of common biological underpinnings that may influence the regulation of normal cognition and mood, on the one hand, and the central nervous system (CNS) circuits that regulate energy balance on the other. Thus the purpose of this article is to review a handful of the neurochemical systems implicated in the regulation of energy homeostasis. Where possible, the authors speculate about how some of these neurochemical systems have been linked to psychiatric disorders. |
| Databáze: | OpenAIRE |
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