Daily Hazard of Acquisition of Methicillin-Resistant Staphylococcus aureus Infection in the Intensive Care Unit
| Autor: | Emma S. McBryde, Caroline Marshall, Denis Spelman, Glenys Harrington |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Methicillin-Resistant Staphylococcus aureus Microbiology (medical) Pediatrics medicine.medical_specialty Meticillin Adolescent Epidemiology Drug resistance medicine.disease_cause Tertiary referral hospital Risk Assessment law.invention Young Adult Risk Factors law Hospital discharge medicine Humans Aged Aged 80 and over Cross Infection business.industry Length of Stay Middle Aged Staphylococcal Infections Hazard Methicillin-resistant Staphylococcus aureus Intensive care unit Intensive Care Units Infectious Diseases Carrier State Emergency medicine Female business Smoothing kernel medicine.drug |
| Zdroj: | Infection Control & Hospital Epidemiology. 30:125-129 |
| ISSN: | 1559-6834 0899-823X 0195-9417 |
| Popis: | Objective.Increasing length of hospital stay is associated with methicillin-resistant Staphylococcus aureus (MRSA) acquisition. The exact risk of becoming colonized with MRSA on a given day has not been clearly elucidated. We determined the hazard of MRSA acquisition in relation to the length of time spent in an intensive care unit in which only standard precautions were used for MRSA-colonized and MRSA-infected patients.Methods.This study took place at a tertiary referral hospital intensive care unit in which patients were screened for MRSA at hospital admission, at hospital discharge, and twice weekly during intensive care unit stay. We analyzed the hazard of MRSA acquisition by using a statistical smoothing kernel for hazard with a width of 5 days. Patients were stratified according to age, sex, medical unit, and length of hospital stay.Results.Of the patients who were at risk of colonization or infection, 12.8% acquired MRSA. The mean length of stay in the intensive care unit was 7.2 days. The daily hazard of acquiring MRSA was less than 1% at admission to the intensive care unit and increased linearly to more than 2% risk per day by day 12, followed by a leveling out of risk.Conclusions.The daily hazard of acquiring MRSA is not constant. This has implications for studies that assume a constant hazard in their analysis and should be considered. |
| Databáze: | OpenAIRE |
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