Bone Regeneration in a Rabbit Critical-Sized Calvarial Model Using Tyrosine-Derived Polycarbonate Scaffolds
| Autor: | Jeffrey O. Hollinger, Bruce Doll, Joachim Kohn, Aniq Darr, Heather H. Waters, Sean McBride, Pedro Alvarez, Amit Vasanji, Maria Hanshella R. Magno, Jinku Kim |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Scaffold Bone Regeneration X-ray microtomography Biomedical Engineering Bone Morphogenetic Protein 2 chemistry.chemical_element Bioengineering Calcium Biochemistry Biomaterials Animal model Implants Experimental Transforming Growth Factor beta Elastic Modulus Animals Humans Polycarbonate Tyrosine Bone regeneration Polycarboxylate Cement Tissue Scaffolds Skull Rabbit (nuclear engineering) X-Ray Microtomography Recombinant Proteins Disease Models Animal chemistry visual_art visual_art.visual_art_medium Cattle Rabbits Biomedical engineering |
| Zdroj: | Tissue Engineering Part A. 18:1132-1139 |
| ISSN: | 1937-335X 1937-3341 |
| Popis: | Porous three-dimensional tyrosine-derived polycarbonate (TyrPC) scaffolds with a bimodal pore distribution were fabricated to mimic bone architecture using a combination of salt-leaching and phase separation techniques. TyrPC scaffolds degraded in register with bone regeneration during the 6-week study period and compressive moduli of the scaffolds were maintained >0.5 MPa at 6 weeks of incubation in PBS at 37 °C. The TyrPC scaffolds either unsupplemented or supplemented with recombinant human bone morphogenetic protein-2 (rhBMP-2) were implanted in a rabbit calvarial critical-sized defect (CSD) model and the TyrPC scaffolds treated with rhBMP-2 or TyrPC coated with calcium phosphate scaffold alone promoted bone regeneration in a rabbit calvarial CSD at 6 weeks postimplantation. A synthetic TyrPC polymeric scaffold either without a biological supplement or with a minimal dose of rhBMP-2 induced bone regeneration comparable to a commercially available bone graft substitute in a nonrodent CSD animal model. |
| Databáze: | OpenAIRE |
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