Dengue infection in neotropical forest mammals
| Autor: | Xavier Deparis, François Catzeflis, Jacques Morvan, Álvaro Aguilar Setién, Mirdad Kazanji, Jean-François Mauffrey, Candimar Colón, Benoit de Thoisy, Anne Lavergne, Adeline Germain, Jorge L. Muñoz-Jordán, Philippe Dussart, Séverine Matheus, Vincent Lacoste, Marguerite Delaval |
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| Přispěvatelé: | Institut Pasteur de la Guyane, Réseau International des Instituts Pasteur (RIIP), CDC, Molecular Virology and Surveillance Laboratory, Dengue Branch, CDC, Laboratoire Population-Environnement-Développement (LPED), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU), Association Kwata, Institut des Sciences de l'Evolution de Montpellier (UMR ISEM), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Institut de recherche pour le développement [IRD] : UR226-Centre National de la Recherche Scientifique (CNRS), Centre International de Recherches Médicales de Franceville (CIRMF), Institut Pasteur [Paris], Hospital de Pediatría, Instituto del Seguro Social, Unidad de Investigación Medica en Immunologiá, Coordinación de Investigación, Hospital de Pediatría, Institut de Médecine Tropicale du Service de Santé des Armées, Armées, Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École Pratique des Hautes Études (EPHE), Institut Pasteur [Paris] (IP) |
| Rok vydání: | 2008 |
| Předmět: |
Serotype
viruses Prevalence MESH: Rodentia MESH: Dengue Dengue virus medicine.disease_cause MESH: Dengue Virus Dengue fever Trees Dengue Rodent Diseases 0302 clinical medicine MESH: Reverse Transcriptase Polymerase Chain Reaction Chiroptera MESH: Animals MESH: Phylogeny Phylogeny 0303 health sciences education.field_of_study Reverse Transcriptase Polymerase Chain Reaction virus diseases MESH: Chiroptera Markov Chains 3. Good health French Guiana Infectious Diseases Liver MESH: RNA Viral [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology Enzootic RNA Viral 030231 tropical medicine Population Molecular Sequence Data Animals Wild Rodentia Biology MESH: Marsupialia Microbiology 03 medical and health sciences MESH: Markov Chains Virology parasitic diseases MESH: French Guiana medicine Animals Humans MESH: Animals Wild Serotyping education 030304 developmental biology MESH: Molecular Sequence Data MESH: Humans fungi Outbreak MESH: Serotyping biochemical phenomena metabolism and nutrition Dengue Virus medicine.disease MESH: Trees Marsupialia Mammal MESH: Rodent Diseases MESH: Liver |
| Zdroj: | Vector-Borne and Zoonotic Diseases Vector-Borne and Zoonotic Diseases, Mary Ann Liebert, 2009, 9 (2), pp.157-70. ⟨10.1089/vbz.2007.0280⟩ Vector-Borne and Zoonotic Diseases, 2009, 9 (2), pp.157-70. ⟨10.1089/vbz.2007.0280⟩ |
| ISSN: | 1557-7759 1530-3667 |
| DOI: | 10.1089/vbz.2007.0280⟩ |
| Popis: | International audience; In South America, dengue is the arbovirus-transmitted disease with the highest incidence. Unlike other arboviruses, wild mammals have no confirmed role in the cycle of dengue in the neotropics, although serological studies have suggested a possible secondary amplification cycle involving mammals other than nonhuman primates. In French Guiana, where all four serotypes (DENV-1, DENV-2, DENV-3, DENV-4) are present, the disease is endemic with outbreak events. To determine whether wild mammals can be infected by DENV, rodents, marsupials, and bats were captured over several periods, from 2001 to 2007, at two sites. The first location is a secondary forest surrounded by an urban area where dengue is endemic. The second location is a forest edge site where the disease has not yet emerged. A total of 10,000 trap-nights were performed and 616 mammals were captured. RNAs representing the four DENV serotypes were detected at both sites by reverse-transcriptase polymerase chain reaction in the livers and/or sera of 92 mammals belonging to 14 out of 32 species distributed among all the orders investigated: Rodentia (33 positive/146 tested), Marsupialia (40/318), and Chiroptera (19/152). Sequence analyses of a portion of the capsid and premembrane junction revealed that mammal strains of DENV-1, DENV-2, DENV-3, and DENV-4 had only 92.6%, 89%, 95%, and 95.8% identity, respectively, with strains circulating in the human population during the same periods. Regarding DENV-2, strains related (99% identity) to those responsible for an epidemic event in humans in French Guiana concurrent to the capture sessions were also evidenced, suggesting that wild mammals in edge habitats can be infected by circulating human strains. Our results demonstrate, for the first time, that neotropical wild mammals can be infected with dengue virus. The question of whether mammals maintain DENV in enzootic cycles and can play a role in its reemergence in human populations remains to be answered. |
| Databáze: | OpenAIRE |
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