The effect of volume infusion on dead space in mechanically ventilated patients with severe asthma
| Autor: | Peter Goulding, Constantine A. Manthous |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Pulmonary and Respiratory Medicine
Artificial ventilation Adult Adolescent medicine.medical_treatment Dead space Status Asthmaticus Plasma Substitutes Sodium Chloride Critical Care and Intensive Care Medicine Hypercapnia Positive-Pressure Respiration Intravascular volume status Pressure Medicine Humans Saline Asthma Mechanical ventilation business.industry Respiration Respiratory Dead Space Carbon Dioxide medicine.disease Respiration Artificial Respiratory failure Anesthesia Fluid Therapy Female Cardiology and Cardiovascular Medicine business Pulmonary Ventilation Respiratory Insufficiency Respiratory minute volume |
| Zdroj: | Chest. 112(3) |
| ISSN: | 0012-3692 |
| Popis: | Mechanical ventilation of patients with severe asthma is associated with elevated airway pressures that may contribute to increased physiologic dead space. To our knowledge, no previous reports have considered the effect of intravascular volume status on dead space fraction. We herein describe three patients whose dead space decreased by a mean of 4.2% in response to intravascular volume expansion with 250 or 500 mL of normal saline solution administered as part of their routine treatment. No significant changes in CO2 production, minute volume, or airway pressures occurred over the time interval. We conclude with a brief discussion of potential mechanisms to explain these findings and their potential clinical application. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|