Serum interleukin-6 concentration in schizophrenia: Elevation associated with duration of illness
| Autor: | Galina V. Shurin, Rohan Ganguli, Amanda V. Gubbi, Jaspreet S. Brar, K. N. Roy Chengappa, Zanwei Yang, Bruce S. Rabin |
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| Rok vydání: | 1994 |
| Předmět: |
Adult
Male Psychosis medicine.medical_specialty medicine.medical_treatment Clinical state Gastroenterology Sex Factors Internal medicine Ethnicity medicine Humans Interleukin 6 Biological Psychiatry Autoantibodies medicine.diagnostic_test biology Interleukin-6 Autoantibody medicine.disease Control subjects Psychiatry and Mental health Cytokine Schizophrenia Immunoassay Immunology biology.protein Cytokines Female Psychology Antipsychotic Agents |
| Zdroj: | Psychiatry Research. 51:1-10 |
| ISSN: | 0165-1781 |
| Popis: | Using an enzyme immunoassay (ELISA), we measured serum interleukin-6 (IL-6) concentration in 128 schizophrenic patients (24 of whom were never medicated) and in 110 normal control subjects. Mean serum IL-6 concentration was significantly higher in the schizophrenic patients as compared with the control subjects (p = 0.009). Comparisons within the patient group revealed that serum IL-6 was significantly correlated with duration of illness (r = 0.32, p = 0.0004). After covariation for duration of illness, there was no relationship between IL-6 levels and the production of autoantibodies, clinical state, or medication status. Thus, elevated serum IL-6 levels in schizophrenia develop during the course of illness and may be related to treatment or to disease progression. |
| Databáze: | OpenAIRE |
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