Increased Bone Mineral Density after Abstinence in Male Patients with Alcohol Dependence
| Autor: | Dong-Wook Jeon, Tae-Hong Song, Sung-Jin Kim, Joo-Cheol Shim, Jung-Joon Moon, Do-Un Jung, Minkyung Oh |
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| Rok vydání: | 2018 |
| Předmět: |
musculoskeletal diseases
medicine.medical_specialty Bone density Osteoporosis Urology 030209 endocrinology & metabolism 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine medicine Pharmacology (medical) Femur 030212 general & internal medicine Femoral neck Bone mineral business.industry Alcohol dependence medicine.disease Osteopenia Alcoholism Psychiatry and Mental health medicine.anatomical_structure Original Article Alcohol abstinence business Alcohol Abstinence |
| Zdroj: | Clinical Psychopharmacology and Neuroscience |
| ISSN: | 2093-4327 1738-1088 |
| DOI: | 10.9758/cpn.2018.16.3.282 |
| Popis: | Objective This study aimed to compare the bone mineral density of male patients with alcohol dependence with that in healthy controls and to assess changes in bone density after abstinence. Methods Forty-four inpatients with confirmed the Diagnostic and Statistical Manual of Mental Disorders, fourth edition diagnosis of alcohol abuse and 42 controls were recruited. Bone density was determined with dual-energy X-ray absorptiometry in the lumbar spine as well as in the femoral neck, trochanter, and Ward's triangle regions of the proximal right femur. Results There were no significant differences in age and body mass index between patients with alcohol dependence and healthy controls. In the alcohol dependence group, osteopenia and osteoporosis were found in 54.5% and 34.1% of the patients, respectively, whereas in the control group, the corresponding values were 45.2% and 11.9% (p=0.001). Although the actual bone density in the femur and the corresponding T-scores were significantly lower in the alcohol dependence group, no significant differences were found in the lumbar spine. In both groups, body mass index showed a significant correlation with bone mineral density in all areas. After 3 to 4 years of abstinence, bone density significantly increased in the lumbar and femur. Conclusion We conclude that bone mineral density in patients with alcohol dependence was significantly lower than that in healthy controls, and the rates of osteopenia and osteoporosis are higher. Importantly, abstinence from alcohol increases bone density. |
| Databáze: | OpenAIRE |
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