Teratoma with somatic-type malignant components of the testis. A review and an update
| Autor: | Maurizio Colecchia, Gregor Mikuz |
|---|---|
| Přispěvatelé: | Mikuz, G, Colecchia, M |
| Rok vydání: | 2012 |
| Předmět: |
Male
Oncology medicine.medical_specialty business.industry Somatic cell Teratoma Cell Biology General Medicine Prognosis medicine.disease Malignancy Pathology and Forensic Medicine Metastasis medicine.anatomical_structure Testicular Neoplasms Internal medicine Humans Medicine Sarcoma Germ cell tumors Radical surgery business Molecular Biology Germ cell |
| Zdroj: | Virchows Archiv. 461:27-32 |
| ISSN: | 1432-2307 0945-6317 |
| Popis: | Malignant transformation of germ cell tumors into somatic malignancy is uncommon. Its presentation differs from series to series, with 43 % of adult cases identified within the primary tumors and the remainder at the time of relapse or in the metastasis. Patients with stage I disease enjoy an excellent prognosis; whereas in metastatic sites when not completely resectable, the somatic type malignancies suffer a dismal prognosis. Radical surgery is significant for the prospects of cure and is standard chemotherapy for germ cell tumors; a transformation-oriented treatment can be effective for these patients. A deeper understanding of the biology of this phenomenon is essential for clinicians involved in such malignancies in order to permit a better control of the disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink