Mammary neuroendocrine carcinoma with mucinous differentiation: A clinicopathological study of 15 cases
| Autor: | Chiraz Ben Ayed, J. Feki, Slim Charfi, Tahya Boudawara-Sellami, Kais Chaabane, Sameh Ellouze, Jamel Daoud, Mounir Frikha, Hela Mnif |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Cancer Research Pathology medicine.medical_specialty Proliferative index Estrogen receptor Breast Neoplasms Metastasis Diagnosis Differential Biomarkers Tumor Humans Medicine Neuroendocrine carcinoma Mastectomy Extended Radical Aged business.industry Mucin General Medicine Middle Aged medicine.disease Adenocarcinoma Mucinous Immunohistochemistry Carcinoma Neuroendocrine Oncology Female Differential diagnosis business Breast carcinoma Follow-Up Studies |
| Zdroj: | Breast Disease. 34:87-93 |
| ISSN: | 1558-1551 0888-6008 |
| DOI: | 10.3233/bd-130356 |
| Popis: | BACKGROUND: Mammary neuroendocrine carcinoma (NEC) displays morphological features including mucinous type. OBJECTIVE: To describe clinicopathological of NEC with mucinous differentiation. METHODS: A total of 15 cases of mammary NEC with mucinous differentiation were reviewed. RESULTS: All patients in this study were women aged from 37 to 78 year olds (median 68.1 years). The tumors ranged in size from 1.2 cm to 16 cm (mean 3.74 cm). The amount of extracellular mucin varied from 10% to 90%. Histological grade was I in 7 cases and II in 8 cases. Immunohistochemically, estrogen receptor (ER) and progesteron receptor (PR) were expressed in 12 and 14 cases, respectively. All tumors were negative for Her-2. Ki-67 proliferative index was lesser than 1% in all cases and no cases had demonstrated p53 overexpression. Three patients died of disease with a follow-up of 3 to 6 months. One patient was alive with metastasis at 96 months. Ten patients were disease free (follow-up range from 15 to 125 months). CONCLUSIONS: Mammary NEC with mucinous differentiation affects mostly older women. All tumors were low grade and immunoreactive for ER/PR and negative for Her-2. Mammary NEC with mucinous differentiation seems associated with well survival parameters. |
| Databáze: | OpenAIRE |
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