MRI profiling of focal cortical dysplasia using multi‐compartment diffusion models

Autor: Thomas S. Jacques, JH Cross, David W. Carmichael, Roxana Gunny, Enrico Kaden, Chris A. Clark, Torsten Baldeweg, Felice D'Arco, Sophie Adler, Konrad Wagstyl, Sara Lorio
Rok vydání: 2020
Předmět:
Male
0301 basic medicine
Adolescent
multi‐compartment diffusion models
Intracellular Space
Inversion recovery
Fluid-attenuated inversion recovery
Lesion
Young Adult
03 medical and health sciences
0302 clinical medicine
Fractional anisotropy
Image Processing
Computer-Assisted
Neurites
Humans
Medicine
Child
Pediatric epilepsy
Epilepsy
Lesion detection
business.industry
Cortical dysplasia
medicine.disease
Magnetic Resonance Imaging
Diffusion Magnetic Resonance Imaging
Diffusion Tensor Imaging
030104 developmental biology
Type iib
Neurology
Child
Preschool
Malformations of Cortical Development
Group I
Full‐length Original Research
Anisotropy
Female
Neurology (clinical)
medicine.symptom
Extracellular Space
business
Nuclear medicine
epileptogenic zone
cortical dysplasia
030217 neurology & neurosurgery
Zdroj: Epilepsia
ISSN: 1528-1167
0013-9580
DOI: 10.1111/epi.16451
Popis: OBJECTIVE Focal cortical dysplasia (FCD) lesion detection and subtyping remain challenging on conventional MRI. New diffusion models such as the spherical mean technique (SMT) and neurite orientation dispersion and density imaging (NODDI) provide measurements that potentially produce more specific maps of abnormal tissue microstructure. This study aims to assess the SMT and NODDI maps for computational and radiological lesion characterization compared to standard fractional anisotropy (FA) and mean diffusivity (MD). METHODS SMT, NODDI, FA, and MD maps were calculated for 33 pediatric patients with suspected FCD (18 histologically confirmed). Two neuroradiologists scored lesion visibility on clinical images and diffusion maps. Signal profile changes within lesions and homologous regions were quantified using a surface‐based approach. Diffusion parameter changes at multiple cortical depths were statistically compared between FCD type IIa and type IIb. RESULTS Compared to fluid‐attenuated inversion recovery (FLAIR) or T1‐weighted imaging, lesions conspicuity on NODDI intracellular volume fraction (ICVF) maps was better/equal/worse in 5/14/14 patients, respectively, while on SMT intra‐neurite volume fraction (INVF) in 3/3/27. Compared to FA or MD, lesion conspicuity on the ICVF was better/equal/worse in 27/4/2, while on the INVF in 20/7/6. Quantitative signal profiling demonstrated significant ICVF and INVF reductions in the lesions, whereas SMT microscopic mean, radial, and axial diffusivities were significantly increased. FCD type IIb exhibited greater changes than FCD type IIa. No changes were detected on FA or MD profiles. SIGNIFICANCE FCD lesion‐specific signal changes were found in ICVF and INVF but not in FA and MD maps. ICVF and INVF showed greater contrast than FLAIR in some cases and had consistent signal changes specific to FCD, suggesting that they could improve current presurgical pediatric epilepsy imaging protocols and can provide features useful for automated lesion detection.
Databáze: OpenAIRE
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