Aminoterminal brain natriuretic peptide levels in children and adolescents after Fontan operation correlate with congestive heart failure
| Autor: | Gerald Tulzer, Roland Gitter, David Vondrys, Elisabeth Schreier-Lechner, Rudolf Mair, Evelyn Lechner, Miklos Pinter |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent medicine.drug_class Normal values Fontan Procedure Severity of Illness Index Immunoenzyme Techniques Young Adult Reference Values Internal medicine Natriuretic Peptide Brain medicine Natriuretic peptide Humans In patient Clinical severity cardiovascular diseases Prospective Studies Child Heart Failure business.industry Vascular surgery medicine.disease Brain natriuretic peptide Peptide Fragments Cardiac surgery Heart failure Child Preschool Pediatrics Perinatology and Child Health cardiovascular system Cardiology Female Cardiology and Cardiovascular Medicine business human activities hormones hormone substitutes and hormone antagonists circulatory and respiratory physiology |
| Zdroj: | Pediatric cardiology. 29(5) |
| ISSN: | 0172-0643 |
| Popis: | The aim of this study was to generate normal values of amino-terminal pro-brain natriuretic peptide (NT-pro-BNP) in children and adolescents after Fontan operation without congestive heart failure (CHF) and to test the hypothesis that plasma levels of NT-pro-BNP correlate with the clinical severity of CHF. NT-pro-BNP plasma levels of 59 consecutive patients, with a median age of 8.4 years, after Fontan operation were measured using an automated enzyme immunoassay. The 97.5th percentile of NT-pro-BNP in patients without CHF was 282.3 pg/ml. The severity of heart failure was quantified by a pediatric cardiologist using the New York University Pediatric Heart Failure Index (NYUPHFI). NT-pro-BNP levels correlated with the NYUPHFI (p = 0.001). In patients with CHF (14/59) the NT-pro-BNP levels were significantly higher (median, 399 pg/ml; range, 140–5440 pg/ml) than in patients without CHF (median, 96 pg/ml; range, 11–376 pg/ml). NT-pro-BNP levels of patients with Fontan circulation without CHF are similar to those of healthy children. Plasma NT-pro-BNP concentrations correlate with the severity of CHF in children and adolescents after Fontan operation. Plasma NT-pro-BNP levels can help clinicians in the detection of CHF in pediatric patients with Fontan circulation. |
| Databáze: | OpenAIRE |
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