Effect of the Antimicrobial Peptide Tritrpticin on the In Vitro Viability and Growth of Trichomonas vaginalis
| Autor: | Luis M. De León-Rodríguez, Alma D. Miranda-Olvera, Mayra C. Rodriguez, Eva E. Avila, Fernando Anaya-Velázquez, Verónica Vanesa Infante |
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| Rok vydání: | 2010 |
| Předmět: |
Sexually transmitted disease
medicine.medical_treatment Antimicrobial peptides Antiprotozoal Agents Biology medicine.disease_cause Applied Microbiology and Biotechnology Microbiology Cathelicidin Parasitic Sensitivity Tests Metronidazole Trichomonas vaginalis medicine Humans Microbial Viability Innate immune system Drug Synergism General Medicine Antimicrobial In vitro Sodium Bicarbonate Female Oligopeptides Antimicrobial Cationic Peptides medicine.drug |
| Zdroj: | Current Microbiology. 62:301-306 |
| ISSN: | 1432-0991 0343-8651 |
| Popis: | Antimicrobial peptides are widely distributed in nature; they play important roles in several aspects of innate immunity and may provide a basis for the design of novel therapeutic agents. In this study, C-amidated tritrpticin, a 13 amino acid tryptophan-rich antimicrobial peptide derived from a porcine cathelicidin, was tested against Trichomonas vaginalis, a protozoan that causes a serious non-viral sexually transmitted disease associated with preterm birth, low birth weight, and high risk of HIV-1 infection. Tritrpticin was selected due to its reasonably easy synthesis and because analogs with lower toxicity may be designed. Our results show that tritrpticin-NH(2) at either 100 or 200 μg/ml (52.5 or 105 μM) clearly reduces the viability and growth of Trichomonas vaginalis. Together with tritrpticin-NH(2), sodium bicarbonate further limited trichomonad growth. Additionally, a low concentration of metronidazole (5.8 μM), the most commonly used medication for Trichomonas vaginalis, was more effective against the growth of the parasite when it was combined with tritrpticin-NH(2). |
| Databáze: | OpenAIRE |
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