Creatine reduces collagen accumulation in the kidneys of diabetic db/db mice
| Autor: | Harald Hoeger, H. Gialamas, C. Aufricht, Susanne Fang-Kircher, Kurt R. Herkner, Gert Lubec, Adamiker D, Barbara Lubec |
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| Rok vydání: | 1994 |
| Předmět: |
Blood Glucose
medicine.medical_specialty Arginine Ratón Metabolite Creatine Kidney Diabetes Mellitus Experimental chemistry.chemical_compound Mice Diabetes mellitus Internal medicine medicine Animals Diabetic Nephropathies Binding Sites business.industry Body Weight Biological activity Metabolism medicine.disease Mice Mutant Strains Db/db Mouse Hydroxyproline Endocrinology chemistry Collagen business |
| Zdroj: | Europe PubMed Central |
| ISSN: | 1660-8151 |
| Popis: | In the present study, we tested the hypothesis whether creatine, a metabolite of arginine metabolism, shares the pharmacological activities of arginine reducing collagen accumulation in the diabetic kidney. Ten db/db mice were given, for 3 months, a solution containing a daily dosage of creatine of 50 mg/kg body weight. Eleven db/db mice served as controls. At the end of the 3-month study period, the mean N-carboxymethyllysine concentration in the untreated group was significantly higher than in the treated group (0.163 +/- 0.18 versus 0.096 +/- 0.017 nmol/mumol hydroxyproline, p0.001). Collagen accumulation was also significantly higher in the untreated than in the treated group (2.21 +/- 0.24 versus 1.68 +/- 0.22 mumol hydroxyproline/100 mg kidney weight, p0.001). We conclude that creatine led to a significant reduction in collagen type IV accumulation resembling arginine or aminoguanidine action. We do suggest that the guanidino group common to both compounds is able to block reactive carbonyls. |
| Databáze: | OpenAIRE |
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