Cerebral blood flow and serum neuron-specific enolase in early-onset neonatal sepsis
| Autor: | Menat Allah Ali Shaaban, Ahmed S Farag, Noha M. Barakat, Nehal M El-Raggal, Dina H Salama, Mohammed S El Shimy, Hanan E. Mohamed, Abeer K. El Zohiery, Hebatallah A Shaaban, Rania A. El-Farrash |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Middle Cerebral Artery Anterior Cerebral Artery Systole Enolase Cerebral arteries Diastole Infant Newborn Diseases Sepsis 03 medical and health sciences Young Adult 0302 clinical medicine Risk Factors 030225 pediatrics Internal medicine parasitic diseases medicine Humans Prospective Studies Ultrasonography Doppler Color Inflammation Neonatal sepsis business.industry Infant Newborn Ultrasonography Doppler Cerebral Arteries medicine.disease Fetal Blood Cerebral blood flow Cord blood Cerebrovascular Circulation Phosphopyruvate Hydratase Pediatrics Perinatology and Child Health Cardiology Female Neonatal Sepsis business 030217 neurology & neurosurgery Biomarkers Blood Flow Velocity circulatory and respiratory physiology |
| Zdroj: | Pediatric research. 84(2) |
| ISSN: | 1530-0447 |
| Popis: | Sepsis leads to systemic inflammatory response with cerebral blood flow (CBF) alteration and blood–brain barrier disruption that contribute to sepsis-associated encephalopathy (SAE). We aimed to evaluate cord blood neuron-specific enolase (cNSE) and CBF in early-onset neonatal sepsis (EONS) as predictors of SAE and to define short-term neurodevelopmental outcomes among survivors. cNSE was measured in 200 neonates with antenatal risk factors for EONS, stratified into two groups: sepsis (n = 96) and no-sepsis (n = 104). Trans-cranial Doppler of peak systolic velocities (PSV), end diastolic velocities (EDV) and resistive indices (RI) of anterior (ACA) and middle (MCA) cerebral arteries recorded on day 1 postnatal. Griffiths mental developmental scale (GMDS) was assessed at 6 months. Increased cNSE, PSV, EDV, and decreased RI of both ACA and MCA were found in sepsis group compared to no-sepsis group (p |
| Databáze: | OpenAIRE |
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