Trichomonas vaginalis and HIV infection acquisition: a systematic review and meta-analysis
| Autor: | Piet Cools, Eduard J. Sanders, Tania Crucitti, Mario Vaneechoutte, Simon Chengo Masha |
|---|---|
| Přispěvatelé: | Global Health |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
trichomonas medicine.medical_specialty 030106 microbiology Trichomonas MEDLINE Review Dermatology medicine.disease_cause TRACT INFECTIONS 03 medical and health sciences 0302 clinical medicine systematic review Internal medicine Medicine and Health Sciences medicine 030212 general & internal medicine Trichomoniasis biology business.industry Incidence (epidemiology) SEXUALLY-TRANSMITTED-DISEASES Biology and Life Sciences WOMEN HIV ASSOCIATION biology.organism_classification medicine.disease meta-analysis Infectious Diseases Systematic review Meta-analysis Africa Inclusion and exclusion criteria RISK-FACTORS Trichomonas vaginalis HETEROSEXUAL TRANSMISSION business |
| Zdroj: | Sexually Transmitted Infections SEXUALLY TRANSMITTED INFECTIONS Sexually transmitted infections, 95(1), 36-42. BMJ Publishing Group |
| ISSN: | 1472-3263 1368-4973 |
| DOI: | 10.1136/sextrans-2018-053713 |
| Popis: | ObjectivesTrichomoniasis is the most prevalent curable STI globally, with the highest incidence and prevalence in sub-Saharan Africa (sSA). STIs have largely been associated with an increase in HIV acquisition. Our objective was to assess the existing literature available in English regarding the association of Trichomoniasis and HIV-1 acquisition.MethodsThe review protocol was registered at the International Prospective Register of Systematic Reviews (PROSPERO) under number CRD42018082702. We searched MEDLINE, Embase and Scopus databases to collect articles measuring the association of Trichomonas vaginalis infection and HIV acquisition and performed a meta-analysis and qualitative synthesis of the literature.ResultsWe identified 1806 unduplicated citations, of which 18 papers and 1 conference abstract were eligible for inclusion in the review after applying our inclusion and exclusion criteria. All the studies included in the systematic review had been carried out in sSA. The articles reported various measures of effects, namely: HRs, rate ratios, risk ratios and ORs. In a meta-analysis restricted to 11 studies reporting HR, individuals infected with T. vaginalis were 1.5 times more likely to acquire HIV compared with individuals not infected with T. vaginalis (95% CI 1.3 to 1.7; pConclusionsT. vaginalis is an important factor in HIV acquisition especially in sSA where the prevalence of both T. vaginalis and HIV-1 are high. This systematic review and meta-analysis confirms the evidence that infection with T. vaginalis augments HIV acquisition with 50%. Diagnosis and treatment of T. vaginalis infection in both high-risk and low-risk individuals may be a potential tool to reduce new HIV infections.Trial registration numberCRD42018082702 |
| Databáze: | OpenAIRE |
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