Chemosensitivity of murine renal carcinoma
| Autor: | Olsson Ca, de Vere White R, Ki Hong W, Tannenbaum M |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Male
Pathology medicine.medical_specialty Combination therapy Cyclophosphamide Vindesine Urology Antineoplastic Agents Adenocarcinoma Bleomycin Vinblastine Models Biological chemistry.chemical_compound Chlorozotocin medicine Carcinoma Animals Cisplatin Neocarzinostatin business.industry Rats Inbred Strains medicine.disease Kidney Neoplasms Prostatitis Rats chemistry Cancer research Drug Therapy Combination business medicine.drug |
| Zdroj: | Urological research. 10(1) |
| ISSN: | 0300-5623 |
| Popis: | A non-endocrine dependent, spontaneous carcinoma of the kidney in a Wistar-Lewis rat has been studied for sensitivity to chemotherapeutic agents. Two tumour models have been employed. Subcutaneously transplanted flank nodules were used to screen single agents for antitumour activity. A model of intraperitoneal metastatic disease was employed to test further agents which had demonstrated some effectiveness in the nodule model. Single agents that proved ineffective were streptozotocin, neocarzinostatin, chlorozotocin and carminomycin. 5-FU, bleomycin and hydroxyurea were also ineffective at the doses tested. Agents that were effective included cyclophosphamide, adriamycin, vinblastine, vindesin, and maytansine. The most effective combination therapy appeared to be cyclophosphamide with vindesin and cisplatin. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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